用于潜在生物医学应用的聚（ε-己内酯）/季铵化壳聚糖纳米结构静电纺非织造布。
Nanostructured electrospun nonwovens of poly(ε-caprolactone)/quaternized chitosan for potential biomedical applications.
机构信息
Sao Carlos Institute of Chemistry/University of Sao Paulo, Av. Trabalhador sao-carlense, 400-13566-590, Sao Carlos, São Paulo, Brazil.
Sao Carlos Institute of Physics/University of São Paulo, PO Box 369, 13560-970, Sao Carlos, Sao Paulo, Brazil.
出版信息
Carbohydr Polym. 2018 Apr 15;186:110-121. doi: 10.1016/j.carbpol.2018.01.045. Epub 2018 Jan 31.
Blend solutions of poly(ε-caprolactone) (PCL) and N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (QCh) were successfully electrospun. The weight ratio PCL/QCh ranged in the interval 95/5-70/30 while two QCh samples were used, namely QCh1 (DQ¯ = 47.3%; DPv¯ = 2218) and QCh2 (DQ¯ = 71.1%; DPv¯ = 1427). According to the characteristics of QCh derivative and to the QCh content on the resulting PCL/QCh nonwoven, the nanofibers displayed different average diameter (175 nm-415 nm), and the nonwovens exhibited variable porosity (57.0%-81.6%), swelling capacity (175%-425%) and water vapor transmission rate (1600 g m 24 h-2500 g m 24 h). The surface hydrophilicity of nonwovens increases with increasing QCh content, favoring fibroblast (HDFn) adhesion and spreading. Tensile tests revealed that the nonwovens present a good balance between elasticity and strength under both dry and hydrated state. Results indicate that the PCL/QCh electrospun nonwovens are new nanofibers-based biomaterials potentially useful as wound dressings.
聚己内酯（PCL）和 N-（2-羟丙基）-3-三甲基氯化铵壳聚糖（QCh）的共混溶液成功地进行了静电纺丝。PCL/QCh 的重量比在 95/5-70/30 范围内，同时使用了两种 QCh 样品，即 QCh1（DQ¯ = 47.3%；DPv¯ = 2218）和 QCh2（DQ¯ = 71.1%；DPv¯ = 1427）。根据 QCh 衍生物的特性以及所得 PCL/QCh 非织造布上的 QCh 含量，纳米纤维显示出不同的平均直径（175 nm-415 nm），而非织造布表现出不同的孔隙率（57.0%-81.6%）、溶胀能力（175%-425%）和水蒸气透过率（1600 g m 24 h-2500 g m 24 h）。非织造布的表面亲水性随 QCh 含量的增加而增加，有利于成纤维细胞（HDFn）的黏附和铺展。拉伸试验表明，非织造布在干燥和水合状态下均具有良好的弹性和强度平衡。结果表明，PCL/QCh 静电纺非织造布是一种新型的基于纳米纤维的生物材料，可能有用作伤口敷料。
Zotero 插件