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尼莫地平神经保护作用的研究热点与未来方向

Hot spots and future directions of research on the neuroprotective effects of nimodipine.

作者信息

Li Runhui

机构信息

Department of Neurology, Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.

出版信息

Neural Regen Res. 2014 Nov 1;9(21):1933-8. doi: 10.4103/1673-5374.145365.

DOI:10.4103/1673-5374.145365
PMID:25558246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4281435/
Abstract

Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.

摘要

钙拮抗剂因其血管保护和神经保护作用而广泛应用于缺血性脑血管疾病的临床治疗。尼莫地平作为一种典型的钙拮抗剂，能够穿过血脑屏障，选择性地作用于靶组织的神经元和血管，从而发挥神经保护作用。本研究的目的是探讨尼莫地平神经保护作用的研究热点和未来趋势。我们检索了2000年至2014年期间被科学引文索引数据库收录的425篇关于尼莫地平神经保护作用的文章。使用文献分析报告和科学引文中的衍生信息功能以及信息可视化软件CiteSpace III对检索到的文章进行分析。绘制了参考文献共被引网络，并使用这些出版物中的高频关键词来分析尼莫地平神经保护的研究前沿和发展趋势。根据这些共被引聚类，尼莫地平神经保护的研究前沿是使用随机对照试验来研究尼莫地平对蛛网膜下腔出血的干预。对用关键词标记的热点进行时区视图分析，尼莫地平神经保护领域的研究热点是尼莫地平药理学与治疗学、血脑屏障、试验和抗血管痉挛。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/ffbad0db5f8a/NRR-9-1933-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/ffbad0db5f8a/NRR-9-1933-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/1e44849ac79d/NRR-9-1933-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/949701000b17/NRR-9-1933-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/3dc2f6d7ca01/NRR-9-1933-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/b9033513daec/NRR-9-1933-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/c32fa11b562d/NRR-9-1933-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/c471bfb8ba55/NRR-9-1933-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/1bdbc5b74380/NRR-9-1933-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c3/4281435/ffbad0db5f8a/NRR-9-1933-g010.jpg

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本文引用的文献

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Non-hypotensive dose of telmisartan and nimodipine produced synergistic neuroprotective effect in cerebral ischemic model by attenuating brain cytokine levels.替米沙坦和尼莫地平的非低血压剂量通过降低脑内细胞因子水平，在脑缺血模型中产生协同神经保护作用。
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