Rai Jasuma Jagdish, Kalantharakath Thanveer
Department of Periodontics, K. M. Shah Dental College and Hospital, Sumadeep Vidyapeeth, Gujarat, India.
Department of Public Health Dentistry, K. M. Shah Dental College and Hospital, Sumadeep Vidyapeeth, Gujarat, India.
J Int Soc Prev Community Dent. 2014 Dec;4(Suppl 2):S78-92. doi: 10.4103/2231-0762.146207.
Biomimetic materials are widely used in the treatment of osseous defects as an alternative to autogenous bone graft. The aim of this article was to review the literature and compare the quality of published articles on biomimetic ceramic material used for periodontal regeneration in the treatment of infrabony defects and to discuss the future direction of research. The bibliographic databases PubMed, Ebsco, and Google Scholar were searched from January 2000 to March 2014 for randomized control trials in which biomimetic ceramic graft material was compared with open flap debridement or in combination with any other regenerative material. To avoid the variability of the search terms, the thesaurus Mesh was used. The primary outcome variable assessed was clinical attachment level (CAL). The screening of eligible studies, assessment of the methodological quality of the trials, and data extraction were performed by two observers independently. Twenty-six articles were identified and included in this systematic review. The primary outcome was CAL. Out of the 26 studies, 24 showed more than 2 mm of CAL gain. The difference in CAL change between test and control groups varied from 1.2 mm to 5.88 mm with respect to different biomaterials/biomimetic materials, which was clinically and statistically significant. Meta-analysis was not done due to heterogeneity in results between studies. Overall, biomaterials were found to be more effective than open flap debridement in improving the attachment levels in intraosseous defects. Future research should aim at increasing the osteoinductive capacity of these biomimetic graft materials.
仿生材料作为自体骨移植的替代物被广泛应用于骨缺损的治疗。本文的目的是回顾文献并比较已发表的关于用于治疗骨下袋缺损的牙周再生的仿生陶瓷材料的文章质量，并讨论未来的研究方向。检索了2000年1月至2014年3月的文献数据库PubMed、Ebsco和谷歌学术，查找将仿生陶瓷移植材料与开放瓣清创术或与任何其他再生材料联合使用进行比较的随机对照试验。为避免检索词的可变性，使用了主题词表Mesh。评估的主要结局变量是临床附着水平（CAL）。由两名观察者独立进行符合条件的研究筛选、试验方法学质量评估和数据提取。确定了26篇文章并纳入本系统评价。主要结局是CAL。在这26项研究中，24项显示CAL增加超过2mm。就不同的生物材料/仿生材料而言，试验组和对照组之间CAL变化的差异在1.2mm至5.88mm之间，具有临床和统计学意义。由于研究结果的异质性，未进行荟萃分析。总体而言，发现生物材料在改善骨内缺损的附着水平方面比开放瓣清创术更有效。未来的研究应旨在提高这些仿生移植材料的骨诱导能力。
