Lewis A G, Cleator G M, Klapper P E, Templeton P P, Longson M
Dept of Medical Microbiology, University of Manchester, Medical School, UK.
Res Virol. 1989 Sep-Oct;140(5):443-51. doi: 10.1016/s0923-2516(89)80122-0.
The anti-human herpesvirus type 1 (herpes simplex virus 1; HSV1) activity of etoposide (VP-16-213, a semi-synthetic derivative of epipodophyllotoxin) was investigated in vitro. Etoposide (but not the proprietary solvent in which the compound is usually formulated) demonstrated a significant antiviral action, probably through an effect on virus replication. Etoposide, at 3 micrograms/ml, induced a 50% reduction of HSV1-plaque formation in Vero cells. These findings are considered in the context of the use of etoposide in an in vivo procedure for the diagnosis of herpes encephalitis through virus-specific scintigraphic brain imaging.
研究了依托泊苷（VP - 16 - 213，一种鬼臼毒素的半合成衍生物）对人1型疱疹病毒（单纯疱疹病毒1型；HSV1）的体外活性。依托泊苷（而非该化合物通常配制所用的专有溶剂）表现出显著的抗病毒作用，可能是通过对病毒复制的影响。在3微克/毫升的浓度下，依托泊苷可使Vero细胞中HSV1蚀斑形成减少50%。这些发现是在依托泊苷用于通过病毒特异性脑闪烁成像进行疱疹性脑炎体内诊断的程序的背景下进行考量的。
