Slagowska A, Zgórniak-Nowosielska I, Grzybek J
Department of Virology, Institute of Microbiology, Medical Academy, Kraków, Poland.
Pol J Pharmacol Pharm. 1987 Jan-Feb;39(1):55-61.
The preliminary phytochemical investigations have revealed the presence of flavonoids, iridoids, phenolic acids, saponins, amino acids, free sugars, and mucilages in the lyophilized infusion obtained from flowers of Verbascum thapsiforme Schrad. (FVI). Antiviral activity of the FVI on Herpes simplex type 1 virus (HSV-1) was studied in vitro by the yield reduction test. Decrease in the virus titer amounted to about 2.5 log at the non-toxic concentrations of FVI. The inhibitory effect of FVI on HSV studied by plaque reduction test in Vero cells showed that 50% inhibition of virus plaques occurred at 190 micrograms/ml. The virucidal effect of FVI on HSV was also shown.
初步的植物化学研究表明，从毛蕊花（Verbascum thapsiforme Schrad.）花朵冻干浸液（FVI）中检测到黄酮类化合物、环烯醚萜类化合物、酚酸、皂苷、氨基酸、游离糖和黏液质。通过产量减少试验在体外研究了FVI对单纯疱疹病毒1型（HSV-1）的抗病毒活性。在FVI无毒浓度下，病毒滴度降低约2.5个对数。通过在Vero细胞中进行蚀斑减少试验研究FVI对HSV的抑制作用，结果表明在190微克/毫升时出现50%的病毒蚀斑抑制。FVI对HSV也显示出杀病毒作用。
