来自尾叶罗汉果的两种新香豆素苷。

Two new coumarin glycosides from Herpetospermum caudigerum.

作者信息

Xu Bing, Liu Shuang, Fan Xu-Dong, Deng Li-Qing, Ma Wen-Hui, Chen Min

机构信息

a Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University , Chongqing 400715 , China.

出版信息

J Asian Nat Prod Res. 2015;17(7):738-43. doi: 10.1080/10286020.2014.996137. Epub 2015 Jan 3.

DOI:10.1080/10286020.2014.996137

PMID:25559035

Abstract

Phytochemical investigation on the seeds of Herpetospermum caudigerum afforded two new coumarin glycosides A and B (1 and 2), together with a known compound herpetolide A (3). Their structures were determined by spectroscopic methods, including 2D NMR techniques. Compound 3 exhibited cytotoxicity against HepG2 cells with IC50 value of 6.47 μg/ml. Compound 2 showed anti-hepatitis B virus activity with HBsAg secretion by 33.1% at 200 μg/ml.

摘要

对藏瓜种子进行植物化学研究，得到了两种新的香豆素糖苷A和B（1和2），以及一种已知化合物藏瓜内酯A（3）。通过光谱方法，包括二维核磁共振技术确定了它们的结构。化合物3对HepG2细胞具有细胞毒性，IC50值为6.47μg/ml。化合物2在200μg/ml时具有抗乙型肝炎病毒活性，可使乙肝表面抗原分泌量降低33.1%。