Li Zhoupeng, Kong Dehui, Liu Yongsheng, Li Mingkai
Department of Pharmacology & Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medical of the State Administration of Traditional Chinese Medicine, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shanxi 710032, PR China.
School of Nursing, Army Medical University (Third Military Medical University), Chongqing 400038, PR China.
Genes Dis. 2021 Apr 20;9(1):80-94. doi: 10.1016/j.gendis.2021.03.007. eCollection 2022 Jan.
Infections caused by viruses are one of the foremost causes of morbidity and mortality in the world. Although a number of antiviral drugs are currently used for treatment of various kinds of viral infection diseases, there is still no available therapeutic agent for most of the viruses in clinical practice. Coumarin is a chemical compound which is found naturally in a variety of plants, it can also be synthetically produced possessing diverse biological effects. More recently, reports have highlighted the potential role of coumarin derivatives as antiviral agents. This review outlines the advances in coumarin-based compounds against various viruses including human immunodeficiency virus, hepatitis virus, herpes simplex virus, Chikungunya virus and Enterovirus 71, as well as the structure activity relationship and the possible mechanism of action of the most potent coumarin derivatives.
病毒引起的感染是全球发病和死亡的主要原因之一。尽管目前有多种抗病毒药物用于治疗各类病毒感染疾病，但在临床实践中，大多数病毒仍然没有可用的治疗药物。香豆素是一种天然存在于多种植物中的化合物，也可以通过合成生产，具有多种生物学效应。最近，有报道强调了香豆素衍生物作为抗病毒剂的潜在作用。本文综述了基于香豆素的化合物抗多种病毒（包括人类免疫缺陷病毒、肝炎病毒、单纯疱疹病毒、基孔肯雅病毒和肠道病毒71型）的研究进展，以及最有效的香豆素衍生物的构效关系和可能的作用机制。
