Samoĭlovich E O, L'vov N D, Chepaĭkina T A, Lidak M Iu, Tsvetkov E N, Bobkov A F, Garaev M M, Barinskiĭ I F
Vopr Virusol. 1989 Jul-Aug;34(4):466-74.
Nationally synthesized chemopreparations: phosphonoacetic (PAA), phosphonoformic (PFA) acids and acycloguanosine (Acg) exhibit a marked antiherpetic effect in cell cultures and marked protective effect in herpes meningoencephalitis in mice induced by intraperitoneal inoculation of herpes simplex virus type 1 (HSV-1) (43% PFA, 33% PAA, 25% Acg). Both in vitro and in vivo (mouse meningoencephalitis), PFA (its trisodium salt) on the whole proved to be less toxic than PAA but exerted a higher or similar antiherpetic effect. The combined use of pyrophosphate analogues (PAA, PFA) with Acg is more effective that their use separately both in vitro and in herpes meningoencephalitis in mice an produces an additive effect or one similar to it. Systemic inoculation of interferon inducers, lafarine or ridostine, is effective in herpes meningoencephalitis in mice induced by intraperitoneal inoculation of HSV-1 (the protective effect 33% and 26%, respectively). The combined use of ridostine and PAA in herpes meningoencephalitis in mice led to synergistic effect.
膦甲酸钠（PAA）、膦甲酸（PFA）和阿昔洛韦（Acg）在细胞培养中表现出显著的抗疱疹作用，在通过腹腔接种单纯疱疹病毒1型（HSV-1）诱导的小鼠疱疹性脑膜脑炎中表现出显著的保护作用（PFA为43%，PAA为33%，Acg为25%）。无论是在体外还是体内（小鼠脑膜脑炎），总体而言，PFA（其三钠盐）的毒性低于PAA，但具有更高或相似的抗疱疹作用。焦磷酸盐类似物（PAA、PFA）与Acg联合使用在体外和小鼠疱疹性脑膜脑炎中比单独使用更有效，并产生相加作用或类似相加的作用。全身接种干扰素诱导剂拉法林或利多司汀对腹腔接种HSV-1诱导的小鼠疱疹性脑膜脑炎有效（保护作用分别为33%和26%）。利多司汀和PAA联合用于小鼠疱疹性脑膜脑炎产生协同作用。
