小鼠单纯疱疹病毒性肝炎：膦甲酸钠三钠治疗的效果
Herpes simplex virus hepatitis in mice: effects of treatment with trisodium phosphonoformate.
作者信息
Ulbricht A, Färber I, Wutzler P
出版信息
Acta Virol. 1985 Dec;29(6):493-8.
PMID:2869661
Abstract
Clinical isolates of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) induced focal necrotic hepatitis in ICR/Schö mice. The extent of the hepatitis could be considerably reduced by trisodium phosphonoformate (PFA) administered for 3 days in a daily dose of 400-600 mg/kg. The HSV hepatitis in mice could serve as a suitable model for testing antiherpetic drugs.
摘要
1型单纯疱疹病毒（HSV-1）和2型单纯疱疹病毒（HSV-2）的临床分离株可在ICR/Schö小鼠中诱发局灶性坏死性肝炎。通过每天以400 - 600毫克/千克的剂量给予膦甲酸钠（PFA）3天，肝炎的程度可大幅降低。小鼠中的HSV肝炎可作为测试抗疱疹药物的合适模型。
Zotero 插件