抗病毒药物治疗的小鼠三叉神经节中持续性可再激活的潜伏单纯疱疹病毒感染
Persistent reactivable latent herpes simplex virus infection in trigeminal ganglia of mice treated with antiviral drugs.
作者信息
Svennerholm B, Vahlne A, Lycke E
出版信息
Arch Virol. 1981;69(1):43-8. doi: 10.1007/BF01315264.
PMID:6271097
Abstract
Latent reactivable infection was established with HSV in mouse trigeminal ganglion. A number of antiviral drugs (IUDR, acycloguanosine, Ara-A, PAA and PFA), effective against acute CNS infection with HSV, failed to influence the latent infection once established. Neither lipophilic properties of PFA-derivatives nor the combination of Ara-A and acycloguanosine improved the drug-effects on HSV latency.
摘要
在小鼠三叉神经节中建立了单纯疱疹病毒（HSV）的潜伏性可再激活感染。一些对HSV急性中枢神经系统感染有效的抗病毒药物（碘苷、阿昔洛韦、阿糖腺苷、磷乙酸和磷甲酸），一旦潜伏感染建立，就无法对其产生影响。磷甲酸衍生物的亲脂性以及阿糖腺苷和阿昔洛韦的联合使用都没有改善药物对HSV潜伏感染的效果。
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