巴西罗勒精油对豚鼠回肠的解痉作用。

Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum.

作者信息

Souza Sylvia D F, Franca Carolina S L, Niculau Edenilson S, Costa Larissa C B, Pinto José E B, Alves Péricles B, Marçal Rosilene M

机构信息

a Department of Pharmacy , Federal University of Sergipe , Av. Marechal Rondon, s/n, Rosa Elze, CEP 49.100-000, São Cristovão, Sergipe , Brazil.

b Department of Chemistry , Federal University of Sergipe , Sergipe , Brazil.

出版信息

Nat Prod Res. 2015;29(22):2125-8. doi: 10.1080/14786419.2014.989392. Epub 2015 Jan 6.

DOI:10.1080/14786419.2014.989392

PMID:25560465

Abstract

Ocimum selloi is an herbal species popularly used in Brazil as antispasmodic. Herein, we report the antispasmodic effect of O. selloi essential oil (OS) in segments of guinea-pig ileum. OS did not reduce the tonus of the ileum. In contrast, OS reduced the contraction induced by carbachol (100 μM), BaCl2 (0.03 M) and low- and high-K(+) concentrations (25 and 60 mM, respectively). OS shifted the concentration-response curve for calcium to the right in a parallel manner. GC/MS analysis showed that OS consists mostly of methyl chavicol (97.57%). These results suggest that OS antispasmodic effect is mediated through calcium channel blockade. In addition, OS effect and mode of action could be accounted for methyl chavicol.

摘要

巴西罗勒是一种在巴西广泛用作抗痉挛药物的草本植物。在此，我们报告了巴西罗勒精油（OS）对豚鼠回肠段的抗痉挛作用。OS并未降低回肠的张力。相反，OS可降低由卡巴胆碱（100μM）、氯化钡（0.03M）以及低钾和高钾浓度（分别为25mM和60mM）诱导的收缩。OS以平行方式将钙的浓度-反应曲线向右移动。气相色谱/质谱分析表明，OS主要由甲基丁香酚（97.57%）组成。这些结果表明，OS的抗痉挛作用是通过钙通道阻滞介导的。此外，OS的作用及作用方式可能归因于甲基丁香酚。