高良姜精油对大鼠回肠的肌松和解痉作用。

Myorelaxant and antispasmodic effects of the essential oil of Alpinia speciosa on rat ileum.

作者信息

Bezerra M A, Leal-Cardoso J H, Coelho-De-Souza A N, Criddle D N, Fonteles M C

机构信息

Centro de Ciências da Saúde, Universidade Vale do Acaraú, 850 Avenida da Universidade, Campus da Betânia, CEP 62.040-370, Sobral, CE, Brazil.

出版信息

Phytother Res. 2000 Nov;14(7):549-51. doi: 10.1002/1099-1573(200011)14:7<549::aid-ptr623>3.0.co;2-t.

DOI:10.1002/1099-1573(200011)14:7<549::aid-ptr623>3.0.co;2-t

PMID:11054849

Abstract

The effects of the essential oil of Alpinia speciosa Schum (EOAS) on rat ileum were studied. EOAS (0.1-600 microg/mL) reversibly relaxed ileal basal tonus. Submaximal contractions induced by 60 mM KCl or acetylcholine were concentration dependently inhibited by EOAS with similar IC(50) values ( approximately 44 and 48 microg/mL, respectively). These results show that EOAS possesses both relaxant and antispasmodic actions in the ileum.

摘要

研究了高良姜精油（EOAS）对大鼠回肠的作用。EOAS（0.1 - 600微克/毫升）可使回肠基础张力可逆性松弛。60 mM氯化钾或乙酰胆碱诱导的亚最大收缩被EOAS浓度依赖性抑制，IC50值相似（分别约为44和48微克/毫升）。这些结果表明，EOAS在回肠中具有松弛和抗痉挛作用。