Misdraji Joseph
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mod Pathol. 2015 Jan;28 Suppl 1:S67-79. doi: 10.1038/modpathol.2014.129.
The classification of appendiceal mucinous neoplasms has been controversial, largely focused on a particular subset of low-grade mucinous tumors that, despite their innocuous appearance, can disseminate to the peritoneal cavity as pseudomyxoma peritonei (PMP). Recent WHO classification of these tumors as low-grade appendiceal mucinous neoplasms acknowledges their unique morphologic appearance and biologic behavior. Still, debate about the use of this term and its parameters continues to impede the adoption of consensus classification for appendiceal mucinous neoplasms. The classification of PMP has also been the subject of debate, with international authorities advocating for the use of malignant terminology to describe all grades of PMP, even though some authorities consider low-grade PMP to be dissemination of adenomatous epithelium in the peritoneum. Recent data also emphasize the importance of histologic grade of the peritoneal tumors in defining prognosis of these patients.
阑尾黏液性肿瘤的分类一直存在争议，主要集中在一类特殊的低级别黏液性肿瘤上，这类肿瘤尽管外观无害，但可作为腹膜假黏液瘤（PMP）播散至腹腔。世界卫生组织（WHO）最近将这些肿瘤分类为低级别阑尾黏液性肿瘤，承认了它们独特的形态学表现和生物学行为。然而，关于该术语的使用及其参数的争论仍在继续，阻碍了阑尾黏液性肿瘤共识分类的采用。PMP的分类也一直是争论的焦点，国际权威机构主张使用恶性术语来描述所有级别的PMP，尽管一些权威机构认为低级别PMP是腺瘤样上皮在腹膜的播散。最近的数据还强调了腹膜肿瘤的组织学分级在确定这些患者预后方面的重要性。
