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Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats.

作者信息

Brindha E, Rajasekapandiyan M

机构信息

Department of Biotechnology, Muthaymmal College of Arts and Science , Rasipuram, Namakkal DT, Tamil Nadu , India and.

出版信息

Toxicol Mech Methods. 2015 Feb;25(2):150-4. doi: 10.3109/15376516.2014.1003421. Epub 2015 Feb 17.

DOI:10.3109/15376516.2014.1003421
PMID:25560919
Abstract

This study was aimed to evaluate the preventive role of phytic acid on lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for two days showed a significant increase in the activities of lysosomal enzymes (glucuronidase, N-acetyl glucosaminidase, galactosidase, cathepsin-B and cathepsin-D) were increased significantly in serum and the heart of ISO-induced rats, but the activities of glucuronidase and cathepsin-D were decreased significantly in the lysosomal fraction of the heart. Pretreatment with phytic acid (25 and 50 mg/kg) daily for a period of 56 d positively altered activities of lysosomal hydrolases in ISO-induced rats. Thus, phytic acid possesses a cardioprotective effect in ISO-induced MI in rats.

摘要

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