Pezeshki Rad Masoud, Farrokh Donya, Vakili Rahim, Omidbakhsh Mozhgan, Mohammadi Mohaddeseh
Vascular and Endovascular Surgery Research Center, Department of Radiology.
Department of Radiology.
Iran J Pediatr. 2014 Jun;24(3):249-54.
Carotid intima-media thickness (cIMT) has been known as a criterion of generalized atherosclerosis and a marker of cardiovascular disease progression in many studies which can be measured by ultrasound using high-resolution device.
This is a case-control study. A total of 40 children (16 males and 24 females) with type1 diabetes mellitus and control group consisting of equal numbers (17 males and 23 females) who were otherwise healthy were included in the study from May 2007 to January 2008. The two groups were age matched, with the mean age of 10.56±3.21 years in control group and 10.67±4.18 years in diabetic patients. Left and right cIMT were measured by ultrasound. Findings : There was a significant difference between case and control subjects in terms of mean cIMT (P<0.001). cIMT was significantly higher in the diabetic group. Among variables including age, BMI and diabetes, diabetes was the only influential parameter in this respect. The mean time length of type 1 diabetes in our diabetic group was reported 4.24±3.02 years, with a minimum of four months and a maximum of ten years. There was a statistically significant difference between the two diabetic patients with below and above four years of disease duration (P=0.03 for right carotid artery and P=0.01 for left carotid artery).
cIMT has been identified as an early indicator of atherosclerosis in many studies. It increases in patients with type 1 diabetes as the disease progresses and this can be followed by macro and microvascular atherosclerotic changes.
在许多研究中，颈动脉内膜中层厚度（cIMT）已被视为全身性动脉粥样硬化的一项标准以及心血管疾病进展的一个标志物，其可通过使用高分辨率设备的超声进行测量。
这是一项病例对照研究。2007年5月至2008年1月，共纳入40名1型糖尿病患儿（16名男性和24名女性）以及由数量相等（17名男性和23名女性）的健康儿童组成的对照组。两组年龄匹配，对照组平均年龄为10.56±3.21岁，糖尿病患者平均年龄为10.67±4.18岁。通过超声测量左右两侧的cIMT。结果：病例组和对照组在平均cIMT方面存在显著差异（P<0.001）。糖尿病组的cIMT显著更高。在年龄、体重指数和糖尿病等变量中，糖尿病是这方面唯一有影响的参数。我们糖尿病组1型糖尿病的平均病程报告为4.24±3.02年，最短4个月，最长10年。病程低于4年和高于4年的两组糖尿病患者之间存在统计学显著差异（右侧颈动脉P = 0.03，左侧颈动脉P = 0.01）。
在许多研究中，cIMT已被确定为动脉粥样硬化的早期指标。随着1型糖尿病病情进展，cIMT会升高，随后可能会出现大血管和微血管的动脉粥样硬化改变。
