Öztürk Mehmet, Yildirim Ruken
Department of Pediatric Radiology, Diyarbakır Children's Hospital, Diyarbakır, Turkey.
Department of Pediatric Endocrinology, Diyarbakır Children's Hospital, Diyarbakır, Turkey.
Pol J Radiol. 2017 Dec 15;82:767-772. doi: 10.12659/PJR.904118. eCollection 2017.
To investigate changes in pancreatic elasticity in children with type 1 diabetes mellitus (T1DM).
MATERIAL/METHODS: The study group consisted of 60 children with T1DM, and the control group was comprised of 60 healthy children. Strain ratios were obtained for the pancreas using ultrasound strain elastography (Toshiba Applio 500 device). Baseline descriptive data, hemoglobin A1c (%) level, time since diagnosis of T1DM (months), and strain ratio values were noted and compared between the 2 groups. Furthermore, correlation between strain ratio values and other variables was investigated.
ROC analysis yielded an optimal cut-off value of 2.245 (AUC=0.999, p<0.001, sensitivity=0.983, specificity=1.00) for the strain ratio. Strain ratio values greater than 2.245 were likely to be pathological, which could be attributed to increased tissue stiffness in T1DM. The strain ratio was significantly higher in T1DM patients than in the control group (3.38±0.66 1.32±0.35; p<0.001). The strain ratio correlated positively with age and duration of T1DM (p<0.001 for both), and there was a correlation between the strain ratio and age in the control group (p=0.011).
Strain elastography is a promising, safe, non-invasive, and practical method for early detection, long-term screening, and follow-up in children with T1DM.
研究1型糖尿病（T1DM）患儿胰腺弹性的变化。
材料/方法：研究组由60例T1DM患儿组成，对照组由60例健康儿童组成。使用超声弹性成像技术（东芝Aplio 500设备）获取胰腺的应变率。记录两组的基线描述性数据、糖化血红蛋白（%）水平、T1DM诊断后的时间（月）以及应变率值，并进行比较。此外，还研究了应变率值与其他变量之间的相关性。
ROC分析得出应变率的最佳截断值为2.245（AUC = 0.999，p < 0.001，敏感性 = 0.983，特异性 = 1.00）。应变率值大于2.245可能为病理性，这可能归因于T1DM中组织硬度增加。T1DM患者的应变率显著高于对照组（3.38±0.66对1.32±0.35；p < 0.001）。应变率与年龄和T1DM病程呈正相关（两者p均< 0.001），且对照组中应变率与年龄之间存在相关性（p = 0.011）。
弹性成像技术是一种有前景、安全、无创且实用的方法，可用于T1DM患儿的早期检测、长期筛查和随访。
