Yan Kelu, Yang Daoshan, Wei Wei, Wang Fen, Shuai Yuanyuan, Li Qiannan, Wang Hua
The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University , Qufu 273165, Shandong P. R. China.
J Org Chem. 2015 Feb 6;80(3):1550-6. doi: 10.1021/jo502474z. Epub 2015 Jan 14.
A novel and convenient silver-mediated radical cyclization method for the synthesis of coumarin derivatives via the direct difunctionalization of alkynoates with α-keto acids through double C-C bond formation under mild conditions has been developed. This new method is highly efficient and practical, and the starting materials are readily prepared. The present method should provide a useful strategy for the construction of coumarin motifs.
已开发出一种新颖且便捷的银介导自由基环化方法，用于在温和条件下通过炔酸酯与α-酮酸的直接双官能化形成两个碳-碳键来合成香豆素衍生物。这种新方法高效且实用，起始原料易于制备。该方法应为香豆素基序的构建提供一种有用的策略。
