Yanni J M, Foxwell M H, Whitman L L, Smith W L, Nolan J C
Department of Pharmacology, A.H. Robins Company Research Laboratories, Richmond, Va.
Int Arch Allergy Appl Immunol. 1989;90(3):307-9. doi: 10.1159/000235043.
The effect of intravenous injections of 5-, 12- and 15-hydroxyeicosatetraenoic acids (HETE), leukotrienes D4 and E4 (LTD4, LTE4) on tracheal mucous gel layer (TMGL) thickness was assessed in rats. When administered in doses ranging from 0.03 pg to 33 ng per rat, the lipoxygenase metabolites produced significant increases in TMGL thickness. The order of potency of the metabolites was 15-HETE greater than 12-HETE greater than or equal to 5-HETE greater than LTD4 greater than or equal to LTE4. Imidazole (31.6 mg/kg), intravenously, significantly decreased this response. These findings suggest that the mono-HETEs, especially 15-HETE, may be important modulators of airway mucus in the rat.
评估了静脉注射5-、12-和15-羟基二十碳四烯酸（HETE）、白三烯D4和E4（LTD4、LTE4）对大鼠气管黏液凝胶层（TMGL）厚度的影响。当以每只大鼠0.03皮克至33纳克的剂量给药时，脂氧合酶代谢产物使TMGL厚度显著增加。代谢产物的效力顺序为15-HETE大于12-HETE大于或等于5-HETE大于LTD4大于或等于LTE4。静脉注射咪唑（31.6毫克/千克）可显著降低这种反应。这些发现表明，单-HETE，尤其是15-HETE，可能是大鼠气道黏液的重要调节因子。
