Department of Psychiatry, Department of Psychiatry, Zuoying Armed Forces, General Hospital, Taiwan.
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Psychiatry Res. 2015 Feb 28;225(3):305-8. doi: 10.1016/j.psychres.2014.12.020. Epub 2014 Dec 20.
B cell lymphoma protein-2 (Bcl-2) may contribute to the pathophysiology of bipolar disorder, and may be involved in the therapeutic action of anti-manic drugs. The aim of this study was to investigate serum levels of Bcl-2 in bipolar patients in a manic phase, and evaluate the Bcl-2 changes after treatment. We consecutively enrolled 23 bipolar inpatients in a manic phase and 40 healthy subjects; 20 bipolar patients were followed up with treatment. Serum Bcl-2 levels were measured with assay kits. All 20 patients were evaluated by examining the correlation between Bcl-2 levels and Young Mania Rating Scale (YMRS) scores, using Spearman׳s correlation coefficients. The serum Bcl-2 levels in bipolar patients in a manic phase were higher than in healthy subjects, but without a significant difference. The YMRS scores were significantly negatively associated with serum Bcl-2 levels (p=0.042). Bcl-2 levels of the 20 bipolar patients were measured at the end of treatment. Using the Wilcoxon Signed Rank test, we found no significant difference in the Bcl-2 levels of bipolar patients after treatment. Our results suggest that Bcl-2 levels might be an indicator of severity of manic symptoms in bipolar patients in a manic phase.
B 细胞淋巴瘤蛋白-2（Bcl-2）可能有助于双相情感障碍的病理生理学，并且可能参与抗躁狂药物的治疗作用。本研究旨在探讨躁狂发作的双相情感障碍患者的血清 Bcl-2 水平，并评估治疗后的 Bcl-2 变化。我们连续招募了 23 名处于躁狂期的双相情感障碍住院患者和 40 名健康受试者；20 名双相情感障碍患者接受了治疗随访。使用试剂盒测量血清 Bcl-2 水平。使用 Spearman 相关系数评估 20 名患者的 Bcl-2 水平与 Young Mania Rating Scale（YMRS）评分之间的相关性。躁狂发作的双相情感障碍患者的血清 Bcl-2 水平高于健康受试者，但无统计学差异。YMRS 评分与血清 Bcl-2 水平呈显著负相关（p=0.042）。在治疗结束时测量了 20 名双相情感障碍患者的 Bcl-2 水平。使用 Wilcoxon 符号秩检验，我们发现治疗后双相情感障碍患者的 Bcl-2 水平无显著差异。我们的结果表明，Bcl-2 水平可能是躁狂发作的双相情感障碍患者躁狂症状严重程度的指标。
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