Tsai Meng-Chang, Huang Tiao-Lai
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Compr Psychiatry. 2017 Apr;74:27-34. doi: 10.1016/j.comppsych.2016.12.008. Epub 2017 Jan 3.
Previous studies have suggested that patients with bipolar disorder might have brain damage. The aim of this study was to investigate the serum levels of brain injury biomarkers and S100A10 in bipolar patients in a manic phase, and evaluate the changes in S100B, neuron specific enolase (NSE), heat shock protein 70 (HSP70) and S100A10 after treatment.
We consecutively enrolled 17 bipolar inpatients in a manic phase and 30 healthy subjects. Serum brain injury biomarkers and S100A10 were measured with assay kits. All patients were evaluated by examining the correlation between brain injury biomarkers and Young Mania Rating Scale (YMRS) scores.
We found significantly decreased S100B levels only in bipolar manic patients after treatment (p=0.002), but S100B levels were not significantly different from those in healthy controls (p>0.05).
Our results indicate there were decreased S100B serum levels in bipolar patients in a manic phase after treatment and that increased serum S100B levels might be a possible indicator of transient disruption of the blood-brain barrier in bipolar patients in a manic phase.
先前的研究表明，双相情感障碍患者可能存在脑损伤。本研究的目的是调查双相情感障碍躁狂期患者脑损伤生物标志物和S100A10的血清水平，并评估治疗后S100B、神经元特异性烯醇化酶（NSE）、热休克蛋白70（HSP70）和S100A10的变化。
我们连续纳入了17名双相情感障碍躁狂期住院患者和30名健康受试者。使用检测试剂盒测量血清脑损伤生物标志物和S100A10。通过检查脑损伤生物标志物与青年躁狂评定量表（YMRS）评分之间的相关性对所有患者进行评估。
我们发现仅在治疗后的双相情感障碍躁狂患者中S100B水平显著降低（p = 0.002），但S100B水平与健康对照组相比无显著差异（p>0.05）。
我们的结果表明，双相情感障碍躁狂期患者治疗后血清S100B水平降低，血清S100B水平升高可能是双相情感障碍躁狂期患者血脑屏障短暂破坏的一个可能指标。
