Roussis Panayiotis C, Giannakopoulos Antonios E, Charalambous Haralambia P, Demetriou Demetra C, Georghiou Georgios P
Department of Civil & Environmental Engineering, University of Cyprus, Nicosia CY-1678, Cyprus.
Biomed Eng Online. 2015 Jan 6;14:1. doi: 10.1186/1475-925X-14-1.
Routine vascular surgery operations involve stitching of disconnected human arteries with themselves or with artificial grafts (arterial anastomosis). This study aims to extend current knowledge and provide better-substantiated understanding of the mechanics of end-to-end anastomosis through the development of an analytical model governing the dynamic behavior of the anastomotic region of two initially separated arteries.
The formulation accounts for the arterial axial-circumferential deformation coupling and suture-artery interaction. The proposed model captures the effects of the most important parameters, including the geometric and mechanical properties of artery and sutures, number of sutures, loading characteristics, longitudinal residual stresses, and suture pre-tensioning.
Closed-form expressions are derived for the system response in terms of arterial radial displacement, anastomotic gap, suture tensile force, and embedding stress due to suture-artery contact interaction. Explicit objective functionalities are established to prevent failure at the anastomotic interface.
The mathematical formulation reveals useful interrelations among the problem parameters, thus making the proposed model a valuable tool for the optimal selection of materials and improved functionality of the sutures. By virtue of their generality and directness of application, the findings of this study can ultimately form the basis for the development of vascular anastomosis guidelines pertaining to the prevention of post-surgery implications.
常规血管外科手术涉及将断开的人体动脉自身或与人工移植物进行缝合（动脉吻合术）。本研究旨在通过建立一个分析模型来控制两条初始分离动脉吻合区域的动态行为，从而扩展现有知识并提供对端到端吻合力学的更充分理解。
该公式考虑了动脉轴向 - 周向变形耦合以及缝线与动脉的相互作用。所提出的模型捕捉了最重要参数的影响，包括动脉和缝线的几何及力学特性、缝线数量、加载特性、纵向残余应力以及缝线预张紧。
推导了系统响应的封闭形式表达式，涉及动脉径向位移、吻合间隙、缝线拉力以及由于缝线与动脉接触相互作用产生的嵌入应力。建立了明确的目标函数以防止吻合界面处的失效。
数学公式揭示了问题参数之间有用的相互关系，从而使所提出的模型成为材料优化选择和缝线功能改进的有价值工具。凭借其通用性和应用的直接性，本研究结果最终可为制定与预防术后影响相关的血管吻合指南奠定基础。
