Zheng Z, Huang X, Schenderlein M, Moehwald H, Xu G-K, Shchukin D G
Max-Planck Institute of Colloids and Interfaces, 14424, Potsdam, Germany.
Nanoscale. 2015 Feb 14;7(6):2409-16. doi: 10.1039/c4nr06378c.
Biological systems with controlled permeability and release functionality, which are among the successful examples of living beings to survive in evolution, have attracted intensive investigation and have been mimicked due to their broad spectrum of applications. We present in this work, for the first time, an example of nuclear pore complexes (NPCs)-inspired controlled release system that exhibits on-demand release of angstrom-sized molecules. We do so in a cost-effective way by stabilizing porous cobalt basic carbonates as nanovalves and realizing pH-sensitive release of entrapped subnano cargo. The proof-of-concept work also consists of the establishment of two mathematical models to explain the selective permeability of the nanovalves. Finally, gram-sized (or larger) quantities of the bio-inspired controlled release system can be synthesized through a scaling-up strategy, which opens up opportunities for controlled release of functional molecules in wider practical applications.
具有可控渗透性和释放功能的生物系统是生物在进化中成功生存的范例之一，因其广泛的应用而受到深入研究并被模仿。在这项工作中，我们首次展示了一个受核孔复合体（NPCs）启发的可控释放系统实例，该系统能按需释放埃级大小的分子。我们通过将多孔碱式碳酸钴稳定化为纳米阀，并实现对包封的亚纳米货物的pH敏感释放，以一种经济高效的方式做到了这一点。概念验证工作还包括建立两个数学模型来解释纳米阀的选择性渗透性。最后，可以通过放大策略合成克级（或更大）数量的这种受生物启发的可控释放系统，这为在更广泛的实际应用中实现功能分子的可控释放开辟了机会。
