Akamaru Yusuke, Takahashi Tsuyoshi, Nishida Toshirou, Omori Takeshi, Nishikawa Kazuhiro, Mikata Shoki, Yamamura Noriyuki, Miyazaki Satoru, Noro Hiroshi, Takiguchi Shuji, Mori Masaki, Doki Yuichiro
Department of Surgery, Japan Community Healthcare Organization, Osaka Hospital, 4-2-78 Fukushima, Fukushima-ku, Osaka, Japan.
J Gastrointest Surg. 2015 Mar;19(3):467-72. doi: 10.1007/s11605-014-2730-y. Epub 2015 Jan 7.
This study aimed to assess the efficacy of daikenchuto (DKT), a commonly prescribed, traditional Japanese herbal medicine, on postoperative intestinal dysfunction after gastric cancer surgery.
Patients with gastric cancer scheduled for a total gastrectomy were randomly assigned before surgery to receive either no treatment (n = 40; control group) or DKT (7.5 g/day, t.i.d.) for 3 months (n = 41) postoperatively. We examined gastrointestinal motility, stool attributes, the quantity of bowel gas, the quality of life, and the incidence of postoperative ileus.
During the hospital stay, significant differences were observed between the DKT group and controls in the number of stools per day (1.1 ± 0.6 vs 0.8 ± 0.4, respectively; P = 0.037) and stool consistencies (Bristol scale ratings were 3.7 ± 0.8 vs 3.1 ± 0.8, respectively; P = 0.041). The DKT group showed significant reductions in gas volume scores, calculated from abdominal radiographs, at 7 days, 1 month, and 3 months after surgery. The groups did not show significant differences in quality of life scores (based on the Gastrointestinal Symptom Rating Scale) or in the incidence of postoperative ileus.
DKT improved bowel movements, stool properties, and bowel gas. These results suggested that DKT promoted early postoperative bowel functions after total gastrectomy.
本研究旨在评估常用的日本传统草药大建中汤（DKT）对胃癌手术后肠道功能障碍的疗效。
计划进行全胃切除术的胃癌患者在手术前被随机分配，术后一组不接受治疗（n = 40；对照组），另一组接受DKT（7.5克/天，每日三次），持续3个月（n = 41）。我们检查了胃肠动力、粪便特征、肠内气体量、生活质量和术后肠梗阻的发生率。
在住院期间，DKT组和对照组在每日排便次数（分别为1.1±0.6次和0.8±0.4次；P = 0.037）和粪便稠度（布里斯托量表评分分别为3.7±0.8和3.1±0.8；P = 0.041）方面存在显著差异。术后7天、1个月和3个月时，DKT组通过腹部X光片计算的气体量评分显著降低。两组在生活质量评分（基于胃肠道症状评分量表）或术后肠梗阻发生率方面没有显著差异。
DKT改善了排便、粪便性质和肠内气体。这些结果表明，DKT促进了全胃切除术后早期肠道功能的恢复。
