Chun Yeoun Sook, Shin Jae-Ho, Park In Ki
Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, Seoul, South Korea.
Department of Ophthalmology, Kyung Hee University College of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.
Invest Ophthalmol Vis Sci. 2015 Jan 6;56(1):451-7. doi: 10.1167/iovs.14-15577.
To compare rates of change between binocular and monocular visual fields.
The study included 1264 visual fields from 62 normal-tension glaucoma patients with a minimum of nine pairs of visual fields for at least 5 years of follow-up. Integrated binocular visual fields (BVFs) were calculated from the two monocular visual fields using a binocular summation. Linear regression of mean deviation (MD) values was used to evaluate the rates of change of the BVFs and monocular visual fields. For each patient, the eye with the worse MD value at baseline was defined as the worse MD eye. The eye with the faster rate of change of monocular visual fields was defined as the faster-changing eye.
The mean age of subjects was 61.8 years at baseline, the mean number of paired visual field tests was 10.2, and the mean follow-up was 8.1 years. The mean rate of change in the BVFs (-0.10 dB/y) was significantly slower than that of the faster-changing eyes (-0.34 dB/y) and faster than that of the slower-changing eyes (-0.06 dB/y; P < 0.001 for both comparisons). Forty-five eyes (64.5%) among the worse MD eyes at baseline were identified as faster-changing eyes at last follow-up, and having a worse MD value at baseline was a risk factor for being the faster-changing eye (P = 0.025).
The rate of change in BVFs was intermediate between the rates of the faster-changing and slower-changing eyes.
比较双眼和单眼视野的变化率。
该研究纳入了62例正常眼压性青光眼患者的1264个视野，这些患者至少有9对视野，且随访时间至少为5年。使用双眼总和法从两个单眼视野计算出综合双眼视野（BVF）。采用平均偏差（MD）值的线性回归来评估BVF和单眼视野的变化率。对于每位患者，将基线时MD值较差的眼定义为MD较差眼。将单眼视野变化率较快的眼定义为变化较快眼。
受试者的平均年龄在基线时为61.8岁，平均配对视野测试次数为10.2次，平均随访时间为8.1年。BVF的平均变化率（-0.10 dB/年）明显慢于变化较快眼的变化率（-0.34 dB/年），且快于变化较慢眼的变化率（-0.06 dB/年；两项比较P均<0.001）。在基线时MD较差的眼中，有45只眼（64.5%）在最后一次随访时被确定为变化较快眼，且基线时MD值较差是成为变化较快眼的一个危险因素（P = 0.025）。
BVF的变化率介于变化较快眼和变化较慢眼的变化率之间。
