Department of Neuroscience, and
Department of Neuroscience, and.
Soc Cogn Affect Neurosci. 2015 Aug;10(8):1153-9. doi: 10.1093/scan/nsu166. Epub 2015 Jan 5.
A single-nucleotide polymorphism on the oxytocin receptor gene (OXTR), rs53576, involving a guanine (G) to adenine (A) substitution has been associated with altered prosocial features. Specifically, individuals with the GG genotype (i.e. the absence of the polymorphism) display beneficial traits including enhanced trust, empathy and self-esteem. However, because G carriers might also be more socially sensitive, this may render them more vulnerable to the adverse effects of a negative social stressor. The current investigation, conducted among 128 white female undergraduate students, demonstrated that relative to individuals with AA genotype, G carriers were more emotionally sensitive (lower self-esteem) in response to social ostracism promoted through an on-line ball tossing game (Cyberball). Furthermore, GG individuals also exhibited altered blood pressure and cortisol levels following rejection, effects not apparent among A carriers. The data support the view that the presence of the G allele not only promotes prosocial behaviors but also favors sensitivity to a negative social stressor.
催产素受体基因（OXTR）上的单核苷酸多态性（rs53576）涉及鸟嘌呤（G）到腺嘌呤（A）的替换，与改变亲社会特征有关。具体来说，具有 GG 基因型（即不存在多态性）的个体表现出有益的特征，包括增强信任、同理心和自尊心。然而，由于 G 携带者也可能更具有社会敏感性，这可能使他们更容易受到负面社会应激源的不利影响。本研究在 128 名白人女性本科学生中进行，结果表明，与 AA 基因型个体相比，G 携带者在通过在线投球游戏（Cyberball）促进的社交排斥中表现出更高的情绪敏感性（自尊心较低）。此外，排斥后 GG 个体的血压和皮质醇水平也发生了改变，而 A 携带者则没有明显的变化。这些数据支持这样一种观点，即 G 等位基因的存在不仅促进亲社会行为，而且有利于对负面社会应激源的敏感性。
