Woods Robbie, Bedard Marc, McQuaid Robyn Jane, Matheson Kim, Anisman Hymie
a Department of Neuroscience , Carleton University , Ottawa , ON , Canada.
b Canadian Centre on Substance Abuse , Ottawa , ON , Canada.
Soc Neurosci. 2018 Jun;13(3):268-276. doi: 10.1080/17470919.2017.1327458. Epub 2017 May 15.
Rejection sensitivity is a cognitive-affective processing disposition that has been linked to interpersonal difficulties. In this regard, the neuropeptide hormone, oxytocin, is thought to underlie social cognitions and behaviors that promote social affiliation. A single nucleotide polymorphism (SNP) on the oxytocin receptor gene (OXTR), in which guanine (G) is substituted for adenine (A), has been associated with less support-seeking behaviors. In the current study, among 376 undergraduate students, it was shown that the relationship between rejection sensitivity and depressive symptoms was mediated by multiple group memberships. Furthermore, the relation between rejection sensitivity and group memberships was only evident among individuals possessing the A allele on the OXTR gene. These findings further support the psychosocial deficits characteristic of individuals possessing the OXTR polymorphism, which in turn is linked to poor mood.
拒绝敏感性是一种认知-情感加工倾向，与人际交往困难有关。在这方面，神经肽激素催产素被认为是促进社会归属感的社会认知和行为的基础。催产素受体基因（OXTR）上的一个单核苷酸多态性（SNP），其中鸟嘌呤（G）取代了腺嘌呤（A），与较少的寻求支持行为有关。在当前的研究中，在376名本科生中发现，拒绝敏感性与抑郁症状之间的关系是由多重群体成员身份介导的。此外，拒绝敏感性与群体成员身份之间的关系仅在拥有OXTR基因A等位基因的个体中明显。这些发现进一步支持了具有OXTR多态性的个体所特有的心理社会缺陷，而这反过来又与情绪不佳有关。
