Chang Hui Hua, Chang Wei Hung, Chi Mei Hung, Peng Yi Chin, Huang Chih-Chun, Yang Yen Kuang, Chen Po See
Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Diabetes Metab Syndr Obes. 2019 Dec 19;12:2707-2713. doi: 10.2147/DMSO.S226245. eCollection 2019.
Previous animal studies have shown that the oxytocin system might affect glucose homeostasis through the hypothalamus-pituitary-adrenal (HPA) axis and peripheral organs. Moreover, whether the effect is stratified by the polymorphism of oxytocin receptor gene () remains unclear.
In this study, we recruited 89 non-diabetic participants. Their plasma oxytocin and serum insulin profiles were obtained, and the polymorphism of rs53576 was genotyped.
There were significant correlations between the oxytocin level and fasting glucose level ( = -0.29, <0.01), insulin level ( = -0.26, = 0.01), and homeostasis model assessment-estimated insulin resistance (HOMA-IR) ( = -0.25, = 0.01), when adjusted for age, gender, and body mass index (BMI). When further considering the stratification effects of variation, we found that the oxytocin level was significantly correlated with the fasting glucose level ( = -0.25, = 0.04), insulin level ( = -0.35, = 0.03), and HOMA-IR ( = -0.35, < 0.01) in subjects with the A allele (n = 75) after adjustment for age, gender, and BMI. In addition, the oxytocin level in those with the GG genotype of was significantly negatively correlated with the leptin level (n = 14, = -0.66, = 0.02).
The results demonstrated that the polymorphism of plays an important role in individual differences in the correlation of oxytocin and glucose homeostasis in non-diabetic subjects.
以往的动物研究表明，催产素系统可能通过下丘脑 - 垂体 - 肾上腺（HPA）轴及外周器官影响葡萄糖稳态。此外，这种效应是否因催产素受体基因（）的多态性而分层仍不清楚。
在本研究中，我们招募了89名非糖尿病参与者。获取他们的血浆催产素和血清胰岛素谱，并对rs53576的多态性进行基因分型。
在调整年龄、性别和体重指数（BMI）后，催产素水平与空腹血糖水平（=-0.29，<0.01）、胰岛素水平（=-0.26，=0.01）以及稳态模型评估 - 估计胰岛素抵抗（HOMA - IR）（=-0.25，=0.01）之间存在显著相关性。当进一步考虑变异的分层效应时，我们发现，在调整年龄、性别和BMI后，携带A等位基因的受试者（n = 75）中，催产素水平与空腹血糖水平（=-0.25，=0.04）、胰岛素水平（=-0.35，=0.03）以及HOMA - IR（=-0.35，<0.01）显著相关。此外，携带GG基因型的受试者（n = 14）中，催产素水平与瘦素水平显著负相关（=-0.66，=0.02）。
结果表明，在非糖尿病受试者中，基因的多态性在催产素与葡萄糖稳态相关性的个体差异中起重要作用。
