Key Laboratory of Synthetic and Natural Functional Molecular Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069 (China).
Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2356-60. doi: 10.1002/anie.201409565. Epub 2015 Jan 7.
Catalytic asymmetric aminative dearomatization of 1-substituted 2-naphthols was successfully implemented with electrophilic azodicarboxylates under the catalysis of chiral Sc(III)/pybox complexes. This intermolecular reaction represents a hitherto unknown enantioselective C-N bond-forming process through direct dearomatization of phenolic compounds to generate chiral nitrogen-containing quaternary carbon stereocenters.
手性 Sc(III)/pybox 配合物催化下，芳基重氮二羧酸酯作为亲电试剂，成功实现了 1-取代 2-萘酚的不对称氨基去芳构化反应。该分子间反应代表了一种前所未知的对映选择性 C-N 键形成过程，通过酚类化合物的直接去芳构化，生成手性含氮季碳中心。
