Cristol J P, Provençal B, Sirois P
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, PQ, Canada.
J Recept Res. 1989;9(4-5):341-67. doi: 10.3109/10799898909066063.
Leukotrienes are metabolites of arachidonic acid catalyzed by a novel lipoxygenase specific for the C-5 position. These fatty acids have many pharmacological properties including smooth muscle contractions and leukocytes activation, and are believed to play a key role in inflammatory and hypersensitivity reactions. Experimental evidence suggests that the action of leukotrienes is mediated by specific receptors. In this paper pharmacological and biochemical data in favor of the existence of leukotriene receptors are presented and hypotheses on the mechanisms of action and transduction are discussed.
白三烯是由一种特异性作用于C-5位的新型脂氧合酶催化花生四烯酸生成的代谢产物。这些脂肪酸具有许多药理特性，包括平滑肌收缩和白细胞激活，并且被认为在炎症和超敏反应中起关键作用。实验证据表明白三烯的作用是由特定受体介导的。本文介绍了支持白三烯受体存在的药理和生化数据，并讨论了其作用机制和转导的假说。
