Goetzl E J
Int Ophthalmol Clin. 1985 Summer;25(2):25-34. doi: 10.1097/00004397-198502520-00005.
The leukotrienes are a family of potent mediators of hypersensitivity and inflammation. The application of sensitive and specific radioimmunoassays for leukotrienes has revealed the generation of significant quantities of several leukotrienes by leukocytes exposed to natural stimuli in the absence of exogenous arachidonic acid. The C6 peptide leukotrienes, LTC4 and LTD4, are potent vasoactive and smooth muscle contractile factors. LTB4 and other di-HETEs stimulate polymorphonuclear leukocyte function and suppress T-lymphocyte activities. The effects of LTB4 on T lymphocytes are subset-specific and include the activation of suppressor and cytotoxic T cells. Receptors for LTB4 on polymorphonuclear leukocytes are specific but exhibit considerable heterogeneity of binding affinity and may mediate different functional effects. The complexity of the pathways of generation and metabolism of leukotrienes, and of the leukotriene receptors, suggest that carefully defined systems will be needed to test the effects of pharmacological inhibitors and antagonists.
白三烯是一类强效的超敏反应和炎症介质。对白三烯进行灵敏且特异的放射免疫测定发现，在没有外源性花生四烯酸的情况下，暴露于天然刺激物的白细胞会产生大量的几种白三烯。C6肽白三烯LTC4和LTD4是强效的血管活性和平滑肌收缩因子。LTB4和其他二羟二十碳四烯酸刺激多形核白细胞功能并抑制T淋巴细胞活性。LTB4对T淋巴细胞的作用具有亚群特异性，包括激活抑制性T细胞和细胞毒性T细胞。多形核白细胞上LTB4的受体具有特异性，但结合亲和力表现出相当大的异质性，可能介导不同的功能效应。白三烯的生成和代谢途径以及白三烯受体的复杂性表明，需要精心定义的系统来测试药理抑制剂和拮抗剂的作用。
