Welge-Lussen Ulrich, Weise Stefanie, Yu Alice L
Department of Ophthalmology, Friedrich-Alexander University, Erlangen, Germany.
Department of Ophthalmology, University of Cologne, Cologne, Germany.
Patient Prefer Adherence. 2014 Dec 18;9:17-23. doi: 10.2147/PPA.S69943. eCollection 2015.
The goal of this study was to determine the adherence of glaucoma patients to their topical glaucoma medication. Furthermore, the relationships between the adherence behavior and the patients' demographic data, clinical characteristics, and their knowledge about glaucoma were evaluated.
This was a prospective study of 123 patients with primary open-angle glaucoma who were given two standardized questionnaires. The first questionnaire at time point T1 comprised a knowledge assessment and the self-reported adherence measures Adherence to Refills and Medication Scale 2 (ARMS2), visual analogue scale for adherence (VAS-AD), and missed doses in the past 14 days. Two months later at time point T2, a second questionnaire reevaluated the adherence measures ARMS2, VAS-AD, and missed doses in the past 14 days.
There was a good correlation among all the three adherence measures at T1 and T2. The mean values of ARMS2 were in the lower range, with 3.38 at T1 and 2.8 at T2. The VAS-AD detected that 18.5% of patients always took their eye drops correctly, and 77.9% of patients reported not to have missed a single dose in the past 14 days. There was no significant correlation between the patients' demographic data or knowledge about glaucoma and the adherence measures ARMS2 or VAS-AD. Among the clinical characteristics, only single-eye blindness showed a significant correlation with VAS-AD.
In this study, no general relationships were found between medication adherence and the patients' demographic data, clinical characteristics, or knowledge about glaucoma. It may be assumed that more individualized strategies are required to optimize adherence behavior.
本研究的目的是确定青光眼患者对局部青光眼药物治疗的依从性。此外，还评估了依从行为与患者人口统计学数据、临床特征以及他们对青光眼的了解之间的关系。
这是一项对123例原发性开角型青光眼患者的前瞻性研究，这些患者被给予两份标准化问卷。在时间点T1的第一份问卷包括知识评估以及自我报告的依从性测量指标——药物续用与用药量表2（ARMS2）、依从性视觉模拟量表（VAS-AD）以及过去14天内漏服的剂量。两个月后的时间点T2，第二份问卷重新评估了ARMS2、VAS-AD以及过去14天内漏服的剂量这些依从性测量指标。
在T1和T2时，所有三项依从性测量指标之间都有良好的相关性。ARMS2的平均值处于较低范围，T1时为3.38，T2时为2.8。VAS-AD检测发现，18.5%的患者总是正确滴眼，77.9%的患者报告在过去14天内没有漏服过一剂。患者的人口统计学数据或对青光眼的了解与依从性测量指标ARMS2或VAS-AD之间没有显著相关性。在临床特征中，只有单眼失明与VAS-AD有显著相关性。
在本研究中，未发现药物依从性与患者的人口统计学数据、临床特征或对青光眼的了解之间存在普遍关系。可以假定需要更具个性化的策略来优化依从行为。
