• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

自组装聚合物纳米颗粒作为用于磁共振成像癌症早期检测的新型智能造影剂。

Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging.

作者信息

Mouffouk Fouzi, Simão Teresa, Dornelles Daniel F, Lopes André D, Sau Pablo, Martins Jorge, Abu-Salah Khalid M, Alrokayan Salman A, Rosa da Costa Ana M, dos Santos Nuno R

机构信息

Chemistry Department, Faculty of Science, Kuwait University, Safat, Kuwait.

IBB - Institute for Biotechnology and Bioengineering, CBME - Centre for Molecular and Structural Biomedicine, Faro, Portugal.

出版信息

Int J Nanomedicine. 2014 Dec 17;10:63-76. doi: 10.2147/IJN.S71190. eCollection 2015.

DOI:10.2147/IJN.S71190
PMID:25565804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4275056/
Abstract

Early cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the presence of acidic cancer tissues. This smart contrast agent consists of pH-sensitive polymeric micelles formed by self-assembly of a diblock copolymer (poly(ethyleneglycol-b-trimethylsilyl methacrylate)), loaded with a gadolinium hydrophobic complex ((t)BuBipyGd) and exploits the acidic pH in cancer tissues. In vitro MRI experiments showed that (t)BuBipyGd-loaded micelles were pH-sensitive, as they turned on their imaging capability only in an acidic microenvironment. The micelle-targeting ability toward cancer cells was enhanced by conjugation with an antibody against the MUC1 protein. The ability of our antibody-decorated micelles to be switched on in acidic microenvironments and to target cancer cells expressing specific antigens, together with its high Gd(III) content and its small size (35-40 nm) reveals their potential use for early cancer detection by MRI.

摘要

早期癌症检测是降低死亡率和癌症管理成本的一个主要因素。在此，我们开发了一种用于磁共振成像（MRI）的智能且靶向的基于胶束的造影剂，它能够在酸性癌组织存在的情况下开启其成像能力。这种智能造影剂由一种双嵌段共聚物（聚（乙二醇 -b- 三甲基硅基甲基丙烯酸酯））自组装形成的pH敏感聚合物胶束组成，负载有钆疏水配合物（(t)BuBipyGd），并利用癌组织中的酸性pH值。体外MRI实验表明，负载(t)BuBipyGd的胶束对pH敏感，因为它们仅在酸性微环境中开启其成像能力。通过与抗MUC1蛋白抗体偶联，胶束对癌细胞的靶向能力得到增强。我们的抗体修饰胶束在酸性微环境中开启并靶向表达特定抗原的癌细胞的能力，连同其高钆（III）含量和小尺寸（35 - 40纳米），揭示了它们在通过MRI进行早期癌症检测中的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/7eee0cee3f39/ijn-10-063Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/a37b98f80f98/ijn-10-063Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/510ecc465732/ijn-10-063Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/98711da6e5f1/ijn-10-063Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/4cb5f01a81dc/ijn-10-063Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/8b79e92199d3/ijn-10-063Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/3c17efd9e967/ijn-10-063Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/f13e4e1477a6/ijn-10-063Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/4f909077655a/ijn-10-063Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/7eee0cee3f39/ijn-10-063Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/a37b98f80f98/ijn-10-063Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/510ecc465732/ijn-10-063Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/98711da6e5f1/ijn-10-063Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/4cb5f01a81dc/ijn-10-063Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/8b79e92199d3/ijn-10-063Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/3c17efd9e967/ijn-10-063Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/f13e4e1477a6/ijn-10-063Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/4f909077655a/ijn-10-063Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18e8/4275056/7eee0cee3f39/ijn-10-063Fig9.jpg

相似文献

1
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging.自组装聚合物纳米颗粒作为用于磁共振成像癌症早期检测的新型智能造影剂。
Int J Nanomedicine. 2014 Dec 17;10:63-76. doi: 10.2147/IJN.S71190. eCollection 2015.
2
Light-triggered concomitant enhancement of magnetic resonance imaging contrast performance and drug release rate of functionalized amphiphilic diblock copolymer micelles.光触发的功能化两亲性嵌段共聚物胶束的磁共振成像对比性能和药物释放速率的协同增强。
Biomacromolecules. 2012 Nov 12;13(11):3877-86. doi: 10.1021/bm301425j. Epub 2012 Oct 9.
3
pH-responsive polymeric micelle based on PEG-poly(β-amino ester)/(amido amine) as intelligent vehicle for magnetic resonance imaging in detection of cerebral ischemic area.基于 PEG-聚（β-氨基酯）/（酰胺基胺）的 pH 响应性聚合物胶束作为磁共振成像的智能载体，用于检测脑缺血区。
J Control Release. 2011 Oct 10;155(1):11-7. doi: 10.1016/j.jconrel.2010.09.012. Epub 2010 Sep 18.
4
Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging.基于两亲性多臂星型嵌段共聚物的多功能单分子胶束用于癌症靶向药物递送和磁共振成像。
Biomaterials. 2011 Sep;32(27):6595-605. doi: 10.1016/j.biomaterials.2011.05.049. Epub 2011 Jun 12.
5
Self-Assembled Nanomicelles as MRI Blood-Pool Contrast Agent.自组装纳米胶束作为 MRI 血池造影剂。
Chemistry. 2018 Jan 26;24(6):1348-1357. doi: 10.1002/chem.201703962. Epub 2017 Dec 27.
6
A polymeric micelle MRI contrast agent with changeable relaxivity.一种弛豫率可变的聚合物胶束磁共振成像造影剂。
J Control Release. 2006 Sep 12;114(3):325-33. doi: 10.1016/j.jconrel.2006.05.030. Epub 2006 Jun 15.
7
Synthesis and experiments of carcinoma vascular endothelial targeting polymeric nano-micelles combining small particle size and supermagnetic sensitivity.合成及实验研究具有小粒径和超顺磁性的肿瘤血管内皮靶向聚合物胶束。
Int J Med Sci. 2018 Mar 8;15(5):498-506. doi: 10.7150/ijms.23146. eCollection 2018.
8
Preparation and in vivo imaging of PEG-poly(L-lysine)-based polymeric micelle MRI contrast agents.基于聚乙二醇-聚（L-赖氨酸）的聚合物胶束磁共振成像造影剂的制备及体内成像
J Control Release. 2009 May 21;136(1):14-20. doi: 10.1016/j.jconrel.2009.01.010. Epub 2009 Jan 23.
9
Surface Modification of Gd Nanoparticles with pH-Responsive Block Copolymers for Use As Smart MRI Contrast Agents.用于智能磁共振成像造影剂的pH响应性嵌段共聚物对钆纳米颗粒的表面改性
ACS Appl Mater Interfaces. 2016 Feb;8(7):5040-50. doi: 10.1021/acsami.5b12463. Epub 2016 Feb 9.
10
Synthesis and in vivo magnetic resonance imaging evaluation of biocompatible branched copolymer nanocontrast agents.生物相容性支化共聚物纳米造影剂的合成及体内磁共振成像评估
Int J Nanomedicine. 2015 Sep 18;10:5895-907. doi: 10.2147/IJN.S88764. eCollection 2015.

引用本文的文献

1
Recent development of pH-responsive theranostic nanoplatforms for magnetic resonance imaging-guided cancer therapy.用于磁共振成像引导癌症治疗的pH响应性诊疗纳米平台的最新进展。
Exploration (Beijing). 2023 Mar 30;3(3):20220002. doi: 10.1002/EXP.20220002. eCollection 2023 Jun.
2
Multimodal Imaging Nanoparticles Derived from Hyaluronic Acid for Integrated Preoperative and Intraoperative Cancer Imaging.基于透明质酸的多模态成像纳米粒子用于集成术前和术中癌症成像。
Contrast Media Mol Imaging. 2017 Sep 11;2017:9616791. doi: 10.1155/2017/9616791. eCollection 2017.

本文引用的文献

1
Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery.将锰卟啉共价连接到载多柔比星的聚乳酸纳米颗粒上，用于潜在的磁共振成像和 pH 敏感药物递送。
Acta Biomater. 2013 Dec;9(12):9434-41. doi: 10.1016/j.actbio.2013.08.018. Epub 2013 Aug 17.
2
Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents.控制镧系纳米粒子的细胞内自组装作为智能分子磁共振对比剂。
Sci Rep. 2013;3:1024. doi: 10.1038/srep01024. Epub 2013 Jan 3.
3
Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities.
多功能纳米粒子：添加靶向和成像功能的成本与效益。
Science. 2012 Nov 16;338(6109):903-10. doi: 10.1126/science.1226338.
4
The MUC1 Ectodomain: A Novel and Efficient Target for Gold Nanoparticle Clustering and Vapor Nanobubble Generation.MUC1 外显子：用于金纳米粒子聚集和蒸汽纳米气泡生成的新型高效靶标。
Theranostics. 2012;2(8):777-87. doi: 10.7150/thno.4494. Epub 2012 Aug 9.
5
Gadolinium loaded nanoparticles in theranostic magnetic resonance imaging.载镧系元素纳米粒子的诊疗磁共振成像。
Biomaterials. 2012 Jul;33(21):5363-75. doi: 10.1016/j.biomaterials.2012.03.084. Epub 2012 Apr 21.
6
Novel aptamer-nanoparticle bioconjugates enhances delivery of anticancer drug to MUC1-positive cancer cells in vitro.新型适体-纳米颗粒生物缀合物增强了抗癌药物在体外向 MUC1 阳性癌细胞的递送。
PLoS One. 2011;6(9):e24077. doi: 10.1371/journal.pone.0024077. Epub 2011 Sep 1.
7
A novel drug vehicle capable of ultrasound-triggered release with MRI functions.一种具有超声触发释放和 MRI 功能的新型药物载体。
Acta Biomater. 2011 Nov;7(11):3927-34. doi: 10.1016/j.actbio.2011.06.038. Epub 2011 Jul 1.
8
Stealth properties of poly(ethylene oxide)-based triblock copolymer micelles: a prerequisite for a pH-triggered targeting system.基于聚环氧乙烷的三嵌段共聚物胶束的隐形特性：pH 触发靶向系统的前提条件。
Acta Biomater. 2011 Oct;7(10):3700-7. doi: 10.1016/j.actbio.2011.06.014. Epub 2011 Jun 17.
9
Improved paramagnetic liposomes for MRI visualization of pH triggered release.用于 MRI 可视化 pH 触发释放的改良超顺磁脂质体。
J Control Release. 2011 Sep 5;154(2):196-202. doi: 10.1016/j.jconrel.2011.05.017. Epub 2011 May 20.
10
Controlled self-assembling of gadolinium nanoparticles as smart molecular magnetic resonance imaging contrast agents.钆纳米粒子作为智能分子磁共振成像造影剂的可控自组装。
Angew Chem Int Ed Engl. 2011 Jul 4;50(28):6283-6. doi: 10.1002/anie.201007018. Epub 2011 May 25.