Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA.
Science. 2012 Nov 16;338(6109):903-10. doi: 10.1126/science.1226338.
Nanoparticle-based drug delivery systems have been developed to improve the efficacy and reduce the systemic toxicity of a wide range of drugs. Although clinically approved nanoparticles have consistently shown value in reducing drug toxicity, their use has not always translated into improved clinical outcomes. This has led to the development of "multifunctional" nanoparticles, where additional capabilities like targeting and image contrast enhancement are added to the nanoparticles. However, additional functionality means additional synthetic steps and costs, more convoluted behavior and effects in vivo, and also greater regulatory hurdles. The trade-off between additional functionality and complexity is the subject of ongoing debate and the focus of this Review.
基于纳米颗粒的药物传递系统已被开发出来，以提高多种药物的疗效并降低其全身毒性。尽管已临床批准的纳米颗粒在降低药物毒性方面一直表现出价值，但它们的使用并未总是转化为改善临床结果。这导致了“多功能”纳米颗粒的发展，其中将靶向和图像对比增强等额外功能添加到纳米颗粒中。然而，额外的功能意味着更多的合成步骤和成本，更复杂的体内行为和效果，以及更大的监管障碍。额外功能与复杂性之间的权衡是正在进行的争论的主题，也是本综述的重点。
