脉络膜厚度存在昼夜变化吗？
[Are there diurnal variations in choroidal thickness?].
作者信息
Pollithy S, Höh A, Dobner B, Auffarth G U, Dithmar S
机构信息
Universitätsaugenklinik Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland,
出版信息
Ophthalmologe. 2015 Aug;112(8):665-9. doi: 10.1007/s00347-014-3177-y.
PURPOSE
Measurement of diurnal choroidal thickness in healthy eyes to investigate thickness variations.
METHODS
A total of 30 healthy eyes in 30 subjects were examined at 6 predefined times within 24 h. Choroidal thickness was visualized using the 7-line scan of spectral domain optical coherence tomography (OCT) with enhanced depth imaging (Spectralis, Heidelberg Engineering) and manually measured by two independent observers. For statistical analyses the mean value was calculated.
RESULTS
The mean choroidal thickness was 270 ± 87 µm. Choroidal thickness changes from baseline ranged between - 47 µm and + 41 µm. There was a statistically significant negative correlation between baseline choroidal thickness and the thickness in examinations at 10:30 am, 1:30 pm and 4:30 pm with the Spearman correlation test. Due to the large diversity in the individual diurnal fluctuations, a significant diurnal variation of choroidal thickness was not observed. There was a significant negative correlation between age and choroidal thickness.
CONCLUSIONS
In this study a significant diurnal variation of choroidal thickness was not observed. Patient age correlated negatively with choroidal thickness.
目的
测量健康眼睛的脉络膜厚度昼夜变化，以研究厚度变化情况。
方法
对30名受试者的30只健康眼睛在24小时内的6个预定义时间进行检查。使用具有增强深度成像功能的光谱域光学相干断层扫描（OCT）的7线扫描（Spectralis，海德堡工程公司）观察脉络膜厚度，并由两名独立观察者手动测量。进行统计分析时计算平均值。
结果
脉络膜平均厚度为270±87μm。脉络膜厚度相对于基线的变化范围在-47μm至+41μm之间。通过Spearman相关性检验，基线脉络膜厚度与上午10:30、下午1:30和下午4:30检查时的厚度之间存在统计学上显著的负相关。由于个体昼夜波动差异较大，未观察到脉络膜厚度有显著的昼夜变化。年龄与脉络膜厚度之间存在显著的负相关。
结论
在本研究中，未观察到脉络膜厚度有显著的昼夜变化。患者年龄与脉络膜厚度呈负相关。
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