Lim V K
Singapore Med J. 1989 Feb;30(1):63-5.
The quinolones are a group of antimicrobial agents that act by inhibiting bacterial DNA gyrases, enzymes essential in DNA replication. Several newer quinolone agents have been introduced recently. These are broad spectrum agents which may be administered orally. In-vitro susceptibility testing of five quinolone agents namely norfloxacin, pefloxacin, enoxacin, ofloxacin and ciprofloxacin against recent clinical bacterial isolates at the General Hospital Kuala Lumpur was performed. The results confirm the broad spectrum and high activity of these agents against these isolates which included Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. The quinolones would provide valuable alternatives in the treatment of infections caused by organisms resistant to the more commonly used antibiotics.
喹诺酮类是一类抗菌药物，其作用机制是抑制细菌DNA旋转酶，这是DNA复制过程中必需的酶。最近引入了几种新型喹诺酮类药物。这些是可口服的广谱药物。对诺氟沙星、培氟沙星、依诺沙星、氧氟沙星和环丙沙星这五种喹诺酮类药物针对吉隆坡总医院近期临床分离的细菌进行了体外药敏试验。结果证实了这些药物对包括铜绿假单胞菌和耐甲氧西林金黄色葡萄球菌在内的这些分离菌株具有广谱和高活性。喹诺酮类药物将为治疗由对更常用抗生素耐药的微生物引起的感染提供有价值的替代方案。
