Buckwalter Joseph A, Tolo Vernon T, O'Keefe Regis J
Department of Orthopaedics and Rehabilitation, College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01008 JPP, Iowa City, IA 52242.
Children's Hospital Los Angeles, Department of Orthopaedics, Keck School of Medicine at University of Southern California, 1520 San Pablo Street, Suite 2000, Los Angeles, CA 90033.
J Bone Joint Surg Am. 2015 Jan 7;97(1):e2. doi: 10.2106/JBJS.N.00245.
High-quality medical care is the result of clinical decisions based upon scientific principles garnered from basic, translational, and clinical research. Information regarding the natural history of diseases and their responses to various treatments is introduced into the medical literature through the approximately one million PubMed journal articles published each year. Pharmaceutical and device companies, universities, departments, and researchers all stand to gain from research publication. Basic and translational research is highly competitive. Success in obtaining research funding and career advancement requires scientific publication in the medical literature. Clinical research findings can lead to changes in the pattern of orthopaedic practice and have implications for the utilization of pharmaceuticals and orthopaedic devices. Research findings can be biased by ownership of patents and materials, funding sources, and consulting arrangements. The current high-stakes research environment has been characterized by an increase in plagiarism, falsification or manipulation of data, selected presentation of results, research bias, and inappropriate statistical analyses. It is the responsibility of the orthopaedic community to work collaboratively with industry, universities, departments, and medical researchers and educators to ensure the integrity of the content of the orthopaedic literature and to enable the incorporation of best practices in the care of orthopaedic patients.
高质量的医疗护理是基于从基础研究、转化研究和临床研究中获取的科学原则所做出的临床决策的结果。关于疾病自然史及其对各种治疗反应的信息，通过每年发表在PubMed上的约100万篇期刊文章被引入医学文献。制药和器械公司、大学、院系以及研究人员都能从研究成果发表中获益。基础研究和转化研究竞争激烈。获得研究资金和职业发展的成功需要在医学文献上发表科研成果。临床研究结果可能会导致骨科医疗实践模式的改变，并对药物和骨科器械的使用产生影响。研究结果可能会受到专利和材料所有权、资金来源以及咨询安排的影响而产生偏差。当前这种高风险的研究环境的特点是抄袭、数据造假或篡改、选择性呈现结果、研究偏差以及不恰当的统计分析有所增加。骨科界有责任与行业、大学、院系以及医学研究人员和教育工作者合作，以确保骨科文献内容的完整性，并将最佳实践纳入骨科患者的护理中。
