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对髋部骨折患者进行早期手术可降低30天死亡率。

Early surgery for patients with a fracture of the hip decreases 30-day mortality.

作者信息

Bretherton C P, Parker M J

机构信息

Orthopaedic Department, Lister Hospital, Stevenage, SG1 4AB, UK.

Peterborough City Hospital, Department Box 211, Peterborough and Stamford Hospitals NHS Foundation Trust, Bretton Gate, Peterborough, PE3 9GZ, UK.

出版信息

Bone Joint J. 2015 Jan;97-B(1):104-8. doi: 10.1302/0301-620X.97B1.35041.

Abstract

There has been extensive discussion about the effect of delay to surgery on mortality in patients sustaining a fracture of the hip. Despite the low level of evidence provided by many studies, a consensus has been accepted that delay of > 48 hours is detrimental to survival. The aim of this prospective observational study was to determine if early surgery confers a survival benefit at 30 days. Between 1989 and 2013, data were prospectively collected on patients sustaining a fracture of the hip at Peterborough City Hospital. They were divided into groups according to the time interval between admission and surgery. These thresholds ranged from < 6 hours to between 49 and 72 hours. The outcome which was assessed was the 30-day mortality. Adjustment for confounders was performed using multivariate binary logistic regression analysis. In all, 6638 patients aged > 60 years were included. Worsening American Society of Anaesthesiologists grade (p < 0.001), increased age (p < 0.001) and extracapsular fracture (p < 0.019) increased the risk of 30-day mortality. Increasing mobility score (p = 0.014), mini mental test score (p < 0.001) and female gender (p = 0.014) improved survival. After adjusting for these confounders, surgery before 12 hours improved survival compared with surgery after 12 hours (p = 0.013). Beyond this the increasing delay to surgery did not significantly affect the 30-day mortality.

摘要

关于髋关节骨折患者手术延迟对死亡率的影响,已经有了广泛的讨论。尽管许多研究提供的证据水平较低,但已达成共识,即延迟超过48小时对生存有害。这项前瞻性观察性研究的目的是确定早期手术是否能在30天时带来生存益处。1989年至2013年期间,前瞻性收集了彼得伯勒市医院髋关节骨折患者的数据。根据入院与手术之间的时间间隔将他们分组。这些阈值范围从小于6小时到49至72小时之间。评估的结果是30天死亡率。使用多变量二元逻辑回归分析对混杂因素进行调整。总共纳入了6638名年龄大于60岁的患者。美国麻醉医师协会分级恶化(p<0.001)、年龄增加(p<0.001)和囊外骨折(p<0.019)增加了30天死亡率的风险。活动能力评分增加(p = 0.014)、简易精神状态检查评分(p<0.001)和女性性别(p = 0.014)改善了生存率。在对这些混杂因素进行调整后,与12小时后手术相比,12小时前手术改善了生存率(p = 0.013)。除此之外,手术延迟增加并未显著影响30天死亡率。

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