Tamura G, Mikawa S, Monma N
Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan.
Acta Pathol Jpn. 1989 Sep;39(9):593-8. doi: 10.1111/j.1440-1827.1989.tb02489.x.
Secretory carcinoma and mucinous carcinoma were found to coexist in the breast of a 67-year-old post-menopausal woman, although the tumors were separated by a thin fibrous septum. Histochemically, intra- and extracellular secretory materials in both carcinomas were strongly positive for alcian blue, PAS and mucicarmine staining, but immunohistochemically negative for alpha-lactalbumin and CEA. Membrane-bound intracytoplasmic vacuoles showing emiocytosis were observed in both the secretory and mucinous carcinomas by electron microscopy. No differences were observed between the tumor cells of secretory carcinoma and those of mucinous carcinoma by histochemistry, immunohistochemistry and electron microscopy. However, there were definite statistically significant differences in the results of morphometry of tumor cell nuclei. Secretory carcinoma is considered to be an anaplastic variant type of mucinous carcinoma.
在一名67岁绝经后女性的乳腺中发现分泌性癌和黏液癌并存，尽管这两种肿瘤被一层薄的纤维间隔分隔开。组织化学检查显示，两种癌的细胞内和细胞外分泌物质对阿尔辛蓝、PAS和黏液卡红染色均呈强阳性，但免疫组织化学检查对α-乳白蛋白和癌胚抗原呈阴性。通过电子显微镜观察，分泌性癌和黏液癌的肿瘤细胞中均可见显示胞吐作用的膜结合胞质内空泡。组织化学、免疫组织化学和电子显微镜检查未发现分泌性癌与黏液癌的肿瘤细胞之间存在差异。然而，肿瘤细胞核形态计量学结果存在明确的统计学显著差异。分泌性癌被认为是黏液癌的一种间变变异型。
