内源性和外源性前列环素在生理和病理情况下胃黏膜中的作用。
The role of endogenous and exogenous prostacyclin in the gastric mucosa under physiological and pathological circumstances.
作者信息
Bálint G A, Varró V
机构信息
First Department of Medicine, University Medical School, Szeged, Hungary.
出版信息
Acta Physiol Hung. 1989;73(2-3):193-7.
PMID:2556887
Abstract
The intracellular effect of exogenously administered prostacyclin in the gastric mucosa seems to be a polyphasic effect, namely: 1. Effect on the cyclic nucleotide (cAMP, cGMP), turnover; 2. Effect on the calmodulin-content; 3. DNA and RNA changes; 4. Influence on protein synthesis; 5. New cell formation. While the endogenous prostacyclin exerts a natural protection against damaging noxae.
摘要
外源性给予的前列环素在胃黏膜中的细胞内效应似乎是一种多相效应，即：1. 对环核苷酸（cAMP、cGMP）周转的影响；2. 对钙调蛋白含量的影响；3. DNA和RNA的变化；4. 对蛋白质合成的影响；5. 新细胞形成。而内源性前列环素对有害刺激发挥天然保护作用。
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