关于内源性前列腺素的作用及外源性前列环素对胃黏膜影响的实验与临床观察。个人观点。
Experimental and clinical observations on the role of endogenous and on the effect of exogenous prostacyclin in gastric mucosa. A personal view.
作者信息
Balint G A
机构信息
Department of Neurology and Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
出版信息
Exp Toxicol Pathol. 1994 Mar;46(1):37-40. doi: 10.1016/S0940-2993(11)80011-4.
In the gastric mucosa the exogenously administered prostacyclin seems to have a polyphasic effect which contains the following consecutive steps: 1. Binding to the cell surface; 2. Effect on the intracellular "second messenger system", i.e. on the cyclic nucleotide (cAMP, cGMP) turnover; 3. Activation of the calmodulin-system; 4. cAMP-dependent protein kinase activation; Nucleic acid,--DNA,RNA,--changes; 6. Influence on protein synthesis and finally; 7. New cell formation. On the other hand, the endogenous (mucosal) prostacyclin exerts a natural protection against different damaging noxae.
在外源性给予的前列环素作用于胃黏膜时，似乎会产生多相效应，包括以下连续步骤：1. 与细胞表面结合；2. 对细胞内“第二信使系统”产生影响，即对环核苷酸（cAMP、cGMP）代谢产生影响；3. 激活钙调蛋白系统；4. 激活依赖cAMP的蛋白激酶；5. 核酸（DNA、RNA）发生变化；6. 影响蛋白质合成；最后，7. 新细胞形成。另一方面，内源性（黏膜）前列环素对不同的损伤性因素发挥天然保护作用。
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