Balint G A
Department of Neurology and Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Exp Toxicol Pathol. 1994 Mar;46(1):37-40. doi: 10.1016/S0940-2993(11)80011-4.
In the gastric mucosa the exogenously administered prostacyclin seems to have a polyphasic effect which contains the following consecutive steps: 1. Binding to the cell surface; 2. Effect on the intracellular "second messenger system", i.e. on the cyclic nucleotide (cAMP, cGMP) turnover; 3. Activation of the calmodulin-system; 4. cAMP-dependent protein kinase activation; Nucleic acid,--DNA,RNA,--changes; 6. Influence on protein synthesis and finally; 7. New cell formation. On the other hand, the endogenous (mucosal) prostacyclin exerts a natural protection against different damaging noxae.
在外源性给予的前列环素作用于胃黏膜时，似乎会产生多相效应，包括以下连续步骤：1. 与细胞表面结合；2. 对细胞内“第二信使系统”产生影响，即对环核苷酸（cAMP、cGMP）代谢产生影响；3. 激活钙调蛋白系统；4. 激活依赖cAMP的蛋白激酶；5. 核酸（DNA、RNA）发生变化；6. 影响蛋白质合成；最后，7. 新细胞形成。另一方面，内源性（黏膜）前列环素对不同的损伤性因素发挥天然保护作用。
