宫颈癌风险增加与更长筛查间隔相关。
Increased cervical cancer risk associated with screening at longer intervals.
作者信息
Kinney Walter, Wright Thomas C, Dinkelspiel Helen E, DeFrancesco Mark, Thomas Cox J, Huh Warner
机构信息
Department of Women's Health, the Permanente Medical Group, Sacramento, California; the Department of Pathology (emeritus) and the Division of Gynecologic Oncology, Columbia University College of Physicians and Surgeons, New York, New York; the University of Connecticut, Farmington, Connecticut; the University of California (retired), Santa Barbara, California; and the University of Alabama, Birmingham, Birmingham, Alabama.
出版信息
Obstet Gynecol. 2015 Feb;125(2):311-315. doi: 10.1097/AOG.0000000000000632.
The 2012 national recommendations for cervical cancer screening will produce a lower level of cervical cancer protection than previously afforded by annual cytology or 3-year cotesting. After a single negative cotest result, the risk of cervical cancer is twice as large at 5 years as it is at 3 years. Modeling published since the 2012 guidelines were drafted indicates that extending the cotesting screening interval from 3 to 5 years at ages 30-64 years will result in an additional 1 woman in 369 compliant with screening receiving a cervical cancer diagnosis during her lifetime, and an additional 1 in 1,639 dying of cervical cancer. The authors believe that a significant number of patients and providers would not choose to accept these additional risks if they understood them, despite the recognition of potential harms associated with more intensive screening.
2012年宫颈癌筛查的国家建议所提供的宫颈癌防护水平，将低于以往每年进行细胞学检查或每3年联合检测所提供的防护水平。在单次联合检测结果为阴性后，5年时患宫颈癌的风险是3年时的两倍。自2012年指南起草以来发表的模型研究表明，将30至64岁女性的联合检测筛查间隔从3年延长至5年，每369名依从筛查的女性中，将有1名女性在其一生中被诊断为宫颈癌，每1639名女性中，将有1名女性死于宫颈癌。作者认为，尽管认识到强化筛查存在潜在危害，但如果大量患者和医疗服务提供者了解这些额外风险，他们不会选择接受这些风险。
Zotero 插件