抗I型胰岛素样生长因子受体抗体在体外培养及无胸腺小鼠体内可抑制肾母细胞瘤生长。
Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.
作者信息
Gansler T, Furlanetto R, Gramling T S, Robinson K A, Blocker N, Buse M G, Sens D A, Garvin A J
机构信息
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
出版信息
Am J Pathol. 1989 Dec;135(6):961-6.
Abstract
The role of the type I insulinlike growth factor (IGF) receptor in regulating growth of Wilms' tumor (WT) was evaluated by examining the effect of antibody-mediated inhibition of this receptor on tumor growth in cell cultures and as heterotransplants in athymic mice. An antibody to the human type I IGF receptor (alpha IR-3) inhibited 125I-IGF-1 binding and prevented stimulation of thymidine incorporation by IGF-1 in vitro. Intraperitoneal administration of alpha IR-3 to nude mice bearing WT heterotransplants prevented tumor growth for 4 weeks and resulted in partial regression of established tumors. These data indicate the importance of IGF action in control of WT growth in vivo, and suggest potential therapeutic application using antigrowth factor receptor antibodies to block growth factor action.
摘要
通过检测抗体介导的Ⅰ型胰岛素样生长因子（IGF）受体抑制对细胞培养中肿瘤生长以及无胸腺小鼠体内异种移植瘤生长的影响，评估了该受体在调控肾母细胞瘤（WT）生长中的作用。一种针对人Ⅰ型IGF受体的抗体（αIR-3）在体外抑制了125I-IGF-1的结合，并阻止了IGF-1对胸苷掺入的刺激作用。对携带WT异种移植瘤的裸鼠腹腔注射αIR-3可使肿瘤生长在4周内受到抑制，并使已形成的肿瘤部分消退。这些数据表明IGF作用在体内控制WT生长中具有重要性，并提示使用抗生长因子受体抗体阻断生长因子作用具有潜在的治疗应用价值。
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