功能定义的白质揭示了人类腹侧颞叶皮质中与类别特异性加工相关的分离通路。
Functionally defined white matter reveals segregated pathways in human ventral temporal cortex associated with category-specific processing.
作者信息
Gomez Jesse, Pestilli Franco, Witthoft Nathan, Golarai Golijeh, Liberman Alina, Poltoratski Sonia, Yoon Jennifer, Grill-Spector Kalanit
机构信息
Neurosciences Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Psychological and Brain Sciences, University of Indiana, Bloomington, IN 47405, USA.
出版信息
Neuron. 2015 Jan 7;85(1):216-227. doi: 10.1016/j.neuron.2014.12.027.
It is unknown if the white-matter properties associated with specific visual networks selectively affect category-specific processing. In a novel protocol we combined measurements of white-matter structure, functional selectivity, and behavior in the same subjects. We find two parallel white-matter pathways along the ventral temporal lobe connecting to either face-selective or place-selective regions. Diffusion properties of portions of these tracts adjacent to face- and place-selective regions of ventral temporal cortex correlate with behavioral performance for face or place processing, respectively. Strikingly, adults with developmental prosopagnosia (face blindness) express an atypical structure-behavior relationship near face-selective cortex, suggesting that white-matter atypicalities in this region may have behavioral consequences. These data suggest that examining the interplay between cortical function, anatomical connectivity, and visual behavior is integral to understanding functional networks and their role in producing visual abilities and deficits.
与特定视觉网络相关的白质属性是否会选择性地影响特定类别处理尚不清楚。在一项新颖的实验方案中，我们在同一受试者身上结合了白质结构、功能选择性和行为的测量。我们发现沿着腹侧颞叶有两条平行的白质通路，分别连接到面部选择性区域或地点选择性区域。这些束中与腹侧颞叶皮质的面部和地点选择性区域相邻部分的扩散特性分别与面部或地点处理的行为表现相关。引人注目的是，患有发展性面孔失认症（脸盲）的成年人在面部选择性皮质附近表现出非典型的结构 - 行为关系，这表明该区域的白质异常可能会产生行为后果。这些数据表明，研究皮质功能、解剖连接性和视觉行为之间的相互作用对于理解功能网络及其在产生视觉能力和缺陷中的作用至关重要。
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