钯催化的 4-芳基-2-甲基-3-丁炔-2-醇与 H-膦酸酯的氧化脱乙酰偶联反应。
Palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with H-phosphonates.
机构信息
The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, People's Republic of China.
出版信息
Org Biomol Chem. 2015 Feb 28;13(8):2432-6. doi: 10.1039/c4ob02410a.
An efficient and generally applicable protocol for palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with dialkyl H-phosphonates has been developed. This methodology provides a new and practical route to alkynylphosphonates using the inexpensive 4-aryl-2-methyl-3-butyn-2-ols as the alkyne sources. This reaction could also be performed with aryl bromides, 2-methyl-3-butyne-2-ol and dialkyl H-phosphonates using the cheap 2-methyl-3-butyne-2-ol as an alkyne source.
已开发出一种高效且普遍适用的钯催化氧化脱乙酰偶联 4-芳基-2-甲基-3-丁炔-2-醇与二烷基 H-膦酸酯的方法。该方法使用廉价的 4-芳基-2-甲基-3-丁炔-2-醇作为炔烃源，为炔基膦酸酯提供了一种新的实用途径。该反应也可以使用便宜的 2-甲基-3-丁炔-2-醇作为炔烃源，用芳基溴化物、2-甲基-3-丁炔-2-醇和二烷基 H-膦酸酯进行。
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