Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing, China.
Chem Commun (Camb). 2010 Feb 7;46(5):677-85. doi: 10.1039/b908581e. Epub 2010 Jan 5.
Direct selective palladium catalyzed C-H functionalization has become a highly attractive strategy in organic synthesis and represents a highly desirable goal. Compared with cross-coupling reactions of C-H bonds with aryl or alkyl halides/pseudohalides, the strategy of cross-coupling reactions of C-H bonds with organometallic reagents is of great significance and obvious advantages. This feature article provides a comprehensive summary of recent advances and an intensive analysis on Pd-catalyzed C-H activation and oxidative coupling with various organometallic reagents.
直接选择性钯催化的 C-H 功能化已成为有机合成中极具吸引力的策略，代表了一个非常理想的目标。与 C-H 键与芳基或烷基卤化物/拟卤化物的交叉偶联反应相比，C-H 键与有机金属试剂的交叉偶联反应策略具有重要意义和明显优势。本文综述了近年来钯催化的 C-H 活化和与各种有机金属试剂的氧化偶联反应的最新进展，并进行了深入分析。
