Mahserejian Shant, Ryan Paul, Djellouli Rabia, Cohen Randy
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:3017-20. doi: 10.1109/EMBC.2014.6944258.
The objective of this study is to assess numerically the effect of applying electrical current on the fibrous tissue growth around polyethylene disk-shaped implants while subcutaneously placed inside 60 day old male Han-Wistar rats. This problem can be formulated as a design problem where the goal is to determine the parameters of a partial differential operator to achieve a desired effect. These electrical current parameters are computed using a regularized iterative method. The obtained results reveal that employing an appropriate electrical current profile can reduce the fibrous tissue concentration around the considered implant by up to 80%. This preliminary study tends to demonstrate the effectiveness of this novel and non-invasive approach to shield the implant from intolerable levels of fibrous tissue growth, which consequently expands the lifespan and functionality of implanted devices, as well as avoids costly and traumatic surgical procedures.
本研究的目的是对置于60日龄雄性Han-Wistar大鼠皮下的聚乙烯圆盘形植入物周围施加电流对纤维组织生长的影响进行数值评估。这个问题可以表述为一个设计问题，其目标是确定一个偏微分算子的参数以达到期望的效果。这些电流参数使用正则化迭代方法进行计算。所得结果表明，采用适当的电流分布可使所考虑植入物周围的纤维组织浓度降低多达80%。这项初步研究倾向于证明这种新颖的非侵入性方法的有效性，该方法可保护植入物免受纤维组织过度生长的影响，从而延长植入设备的使用寿命和功能，同时避免昂贵且具有创伤性的外科手术。
