Butler K, Benghuzzi H, Tucci M, Cason Z
University of Mississippi Medical Center, School of Health Related Professions, Department of Health Science, Jackson 39216, USA.
Biomed Sci Instrum. 1997;34:18-23.
It is well demonstrated in the literature that ceramic drug delivery systems are highly compatible and non-immunogenic. Recent studies in our laboratory have documented the need of an experiment comparing foreign body reactions of several different types of ceramics used for implantation and/or drug delivery. The specific objective of this study was to compare the subcutaneous (s.c.) and intraperitoneal (i.p.) foreign body reactions and biocompatibility of the following implantable materials presently used in orthopedics: ALCAP (aluminum calcium phosphate), HA (hydroxyapatite), and TCP (tricalcium phosphate). The rats were divided into four groups: Group I consisted of 10 rats implanted with ALCAP i.p. and s.c., Group II (n = 10) animals were implanted i.p. and s.c. with HA, Group III consisted of 10 rats implanted i.p. and s.c. with TCP, and Group IV consisted of 10 control animals that were housed under the same environmental conditions as the three experimental groups. At 90 days post-implantation, rats in all four groups were euthanized. The microscopic evaluation of the fibrous tissue surrounding i.p. and s.c. implants revealed the following: 1) all of the ceramic devices had varying degrees of fibrous capsule formation at the time of sacrifice, 2) the thickness of the fibrous tissue capsule was dependent on the type of ceramic used, and 3) the thickness of the fibrous tissue capsules around the subcutaneous devices differed remarkably from implants placed intraperitoneally. The data from this study indicates that capsule formation is dependent upon factors such as ceramic composition and surgical implantation site.
文献充分证明，陶瓷药物递送系统具有高度的兼容性且无免疫原性。我们实验室最近的研究记录了进行一项实验的必要性，该实验旨在比较用于植入和/或药物递送的几种不同类型陶瓷的异物反应。本研究的具体目标是比较目前在骨科中使用的以下可植入材料的皮下（s.c.）和腹腔内（i.p.）异物反应及生物相容性：ALCAP（磷酸铝钙）、HA（羟基磷灰石）和TCP（磷酸三钙）。将大鼠分为四组：第一组由10只大鼠组成，通过腹腔内和皮下植入ALCAP；第二组（n = 10）动物通过腹腔内和皮下植入HA；第三组由10只大鼠组成，通过腹腔内和皮下植入TCP；第四组由10只对照动物组成，它们与三个实验组饲养在相同的环境条件下。植入后90天，对所有四组大鼠实施安乐死。对腹腔内和皮下植入物周围纤维组织的显微镜评估显示如下结果：1）在处死时，所有陶瓷装置都有不同程度的纤维囊形成；2）纤维组织囊的厚度取决于所用陶瓷的类型；3）皮下装置周围纤维组织囊的厚度与腹腔内植入物有显著差异。本研究的数据表明，囊的形成取决于陶瓷成分和手术植入部位等因素。
