Chreiteh Shadi S, Belhage Bo, Hoppe Karsten, Branebjerg Jens, Thomsen Erik V
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:3394-7. doi: 10.1109/EMBC.2014.6944351.
The heart rate variability (HRV) is a commonly used method to quantify the sympathetic and the parasympathetic modulation of the heart rate. HRV is mainly conducted on electrocardiograms (ECG). However, the use of photo-plethysmography (PPG) as a marker of the autonomic tone is emerging. In this study we investigated the feasibility of deriving pulse rate variability (PRV) using PPG signals recorded by a reflectance PPG sensor attached to the chest bone (sternum) and comparing it to HRV. The recordings were conducted on 9 healthy subjects being in a relaxed supine position and under forced respiration, where the subjects were asked to breathe following a visual scale with a rate of 27 breaths/min. HRV parameters such as the mean intervals (meanNN), the standard deviation of intervals (SDNN), the root mean square of difference of successive intervals (RMSSD), and the proportion of intervals differing more than 50 ms (pNN50) were calculated from the R peak-to-R peak (R-R) and pulse-to-pulse (P-P) intervals. In the frequency domain the low and high frequency ratio of the power spectral density (LF/HF) was also computed. The Pearson correlation coefficient showed significant correlation for all the parameters (r > 0.95 with p < 0.001) and the Bland-Altmann analysis showed close agreement between the two methods for all the parameters during resting and forced respiration condition. Thus, PRV analysis using sternal PPG can be an alternative to HRV analysis on healthy subjects at.
心率变异性（HRV）是一种常用的量化心率交感神经和副交感神经调节的方法。HRV主要通过心电图（ECG）进行测量。然而，使用光电容积脉搏波描记法（PPG）作为自主神经张力的标志物正在兴起。在本研究中，我们调查了使用附着在胸骨上的反射式PPG传感器记录的PPG信号推导脉搏率变异性（PRV）并将其与HRV进行比较的可行性。记录是在9名处于放松仰卧位和强制呼吸状态的健康受试者身上进行的，要求受试者按照视觉量表以每分钟27次呼吸的频率呼吸。HRV参数，如平均间期（meanNN）、间期标准差（SDNN）、连续间期差值的均方根（RMSSD）以及差值超过50毫秒的间期比例（pNN50），是根据R波到R波（R-R）和脉搏到脉搏（P-P）间期计算得出的。在频域中，还计算了功率谱密度的低频与高频比值（LF/HF）。皮尔逊相关系数显示所有参数均具有显著相关性（r>0.95，p<0.001），布兰德-奥特曼分析表明在静息和强制呼吸状态下，两种方法对于所有参数均具有良好的一致性。因此，对于健康受试者，使用胸骨PPG进行PRV分析可以替代HRV分析。
