Ma Heather T, Ren Rong, Chen Yang, Griffith James F, Leung Ping-Chung, Zhang Pu
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:4030-3. doi: 10.1109/EMBC.2014.6944508.
Bone marrow was assumed to be negligible on the aspect of bone mechanical behavior, where bone mass and bone mineral density were most studied. As a result, if the bone marrow, especially the marrow fat, plays a role in the bone mechanical properties is unknown yet. Marrow fat content was found increased in osteoporotic bone. However, the relationship between such change of bone marrow and bone strength is not clear yet. This study was proposed to investigate the effect of marrow fat on the bone biomechanical performance by computer simulations. A finite element model was established based on trabecular structure extracted from quantitative CT at L3 vertebrae. Simulations were conducted on the models with and without marrow fat under the same condition, respectively. The results showed that the cancellous bone with marrow fat had a 7.56%~18.81% higher maximum stress in trabeculae. Further, trabeculae with higher Young's modulus tend to sustain a higher maximum compressive stress when considering the marrow fat. As a conclusion, the marrow fat has effect on bone biomechanics, which cannot be ignored. Such effect in osteoporosis should be further investigated in deep.
在对骨量和骨矿物质密度研究最多的骨力学行为方面，骨髓被认为是可忽略不计的。因此，骨髓尤其是骨髓脂肪是否在骨力学性能中发挥作用尚不清楚。研究发现骨质疏松症患者的骨中骨髓脂肪含量增加。然而，骨髓的这种变化与骨强度之间的关系仍不明确。本研究旨在通过计算机模拟研究骨髓脂肪对骨生物力学性能的影响。基于从L3椎体定量CT提取的小梁结构建立了有限元模型。分别在相同条件下对有和没有骨髓脂肪的模型进行模拟。结果表明，含有骨髓脂肪的松质骨小梁的最大应力高出7.56%~18.81%。此外，考虑骨髓脂肪时，具有较高杨氏模量的小梁往往承受更高的最大压缩应力。总之，骨髓脂肪对骨生物力学有影响，不容忽视。在骨质疏松症中的这种影响应进一步深入研究。
