Teixeira Antonio L, de Sousa Rafael Teixeira, Zanetti Marcus V, Brunoni Andre R, Busatto Geraldo F, Zarate Carlos A, Gattaz Wagner F, Machado-Vieira Rodrigo
Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Hum Psychopharmacol. 2015 Jan;30(1):52-6. doi: 10.1002/hup.2450.
TNF system (TNF and its soluble receptors sTNFR1 and 2) has been investigated as a potential molecular target in bipolar disorder. The aim of the study was to compare plasma levels of these receptors in unmedicated bipolar depressed patients compared with healthy controls, and to evaluate the effects of a 6-week lithium treatment on sTNFR1 and sTNFR2 levels.
The study enrolled 29 patients with unmedicated bipolar disorder in a major depressive episode and 27 matched controls. Patients had blood collected at baseline and after 6 weeks of lithium treatment. The concentration of sTNFRs was measured by ELISA.
sTNFR1 and sTNFR2 levels were significantly increased in bipolar depression in comparison with healthy subjects. Lithium treatment did not significantly change sTNFR1 and sTNFR2 levels from baseline to endpoint. There was no correlation between improvement in depressive symptoms and the change in sTNFR1 or sTNFR1 levels.
These results reinforce the involvement of an activated immune response system in the pathophysiology of bipolar disorder, with no impact of lithium treatment on the related biomarkers.
肿瘤坏死因子系统（肿瘤坏死因子及其可溶性受体sTNFR1和sTNFR2）已被作为双相情感障碍潜在的分子靶点进行研究。本研究旨在比较未用药的双相抑郁患者与健康对照者血浆中这些受体的水平，并评估为期6周的锂盐治疗对sTNFR1和sTNFR2水平的影响。
本研究纳入了29例处于重度抑郁发作期的未用药双相情感障碍患者和27例匹配的对照者。患者在基线期和锂盐治疗6周后采集血液。采用酶联免疫吸附测定法（ELISA）测量sTNFRs的浓度。
与健康受试者相比，双相抑郁患者的sTNFR1和sTNFR2水平显著升高。从基线期到终点，锂盐治疗并未显著改变sTNFR1和sTNFR2水平。抑郁症状的改善与sTNFR1或sTNFR2水平的变化之间无相关性。
这些结果进一步证实了激活的免疫反应系统参与双相情感障碍的病理生理学过程，而锂盐治疗对相关生物标志物无影响。
